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Peyton Manning's Broncos hit the road to take on Cam Newton's struggling Panthers.
A betting preview of every game (against the spread) on Sunday and Monday in Week 10.
Locks of the Week
Take the Manning Bros. to cover on the road against a pair of teams with a combined 1–7 record over their last four games.
Giants (-4) at Bengals
The Bungles are on a four-game slide and 1–3 at home, with their only win in Cincy coming against Cleveland in Week 2.
Broncos (-4.5) at Panthers
Other than a 36–7 loss to the Giants in Week 3, the Cats have lost by an average margin of 3.6 points in their other five defeats.
It’s a particularly good week for powerhouse home teams to mop up some of the worst teams in the league.
Ravens (-9) vs. Raiders
From 2007-11, Eastern Time Zone home teams have a 44–15 record against Pacific Time Zone road teams.
Patriots (-11) vs. Bills
New England is 17–1 against Buffalo in its last 18 games, including a 52–28 blowout victory in Week 4.
49ers (-11.5) vs. Rams
The Niners are 9–2 at home under coach Jim Harbaugh, including a 26–0 win over St. Louis at Candlestick Park in Week 13 last year.
Steelers (-12.5) vs. Chiefs
K.C. has a -107 point differential, losing by 13.4 points per game. The No. 1 defense should take advantage of a team with a league-worst 29 turnovers.
Straight Up Upsets
Take the home teams in these division-rivalry showdowns, which are nearly pick ‘em games as it is.
Eagles (+2) vs. Cowboys
Philly’s “Dream Team” beat the Boys twice, 34–7 in Week 8 and 20–7 in Week 16, last season.
Vikings (+2) vs. Lions
The curse of Samantha Steele ends this week for Christian Ponder.
Saints (+3) vs. Falcons
Atlanta has a 2–6 record against New Orleans and a 1–3 mark in the Big un-Easy with Matt Ryan at QB.
Stay away from these contests completely, unless you’re a hometown homer or a degenerate who has to have action.
Bears (-1) vs. Texans
Matt Schaub is 10–1 over his last 11 games; Jay Cutler is 12–1 dating back to before his season-ending injury last year.
Buccaneers (-3) vs. Chargers
The “Muscle Hamster” of Doug Martin will take on the “Turkey Neck” of Norv Turner.
Dolphins (-6) vs. Titans
Tennessee’s Jake Locker returns from a left non-throwing shoulder injury, while Bud Adams gets his firing squad ready.
Seahawks (-6) vs. Jets
The Hawks are 4–0 at CenturyLink Field this season, while the Jetlags have been sluggish wherever they play.