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Chargers at Chiefs Odds, Total and Best Bets for Thursday Night Football

There's an AFC West battle in Kansas City on Thursday night and bettors should bank on a high-scoring game.

"Thursday Night Football" is appointment television as the Chargers travel to face the Chiefs at Arrowhead Stadium for a battle between two AFC West rivals. DraftKings expects this to be a barn burner with the game total set all the way up at 54.5, which is the highest implied total for Week 2.

  • Moneyline: Chargers (+155) | Chiefs (-188)
  • Spread: Chargers +3.5 (-110) | Chiefs -3.5 (-110)
  • Total: 54.5 Over (-110) | Under (-110)

The Chiefs are the home favorites here, but only by -3.5, indicating that in a vacuum these teams are pretty evenly matched.

Related: Chargers vs. Chiefs "Thursday Night Football" Prediction and Preview

In 2021, the Chargers and Chiefs split the series with each team winning the road matchup.

The hometown team’s offense continues to be a juggernaut. Patrick Mahomes threw for five touchdowns and 360 yards on the road against the Cardinals on Sunday and he looked like he didn’t miss Tyreek Hill one bit. Mahomes spread the ball all around and had no shortage of open receivers. Defenses will have trouble figuring out who to shut down in this deep offense. The ground game for the Chiefs was one of the bigger surprises in Week 1. Chiefs running backs combined for 185 all-purpose yards and three touchdowns vs. Arizona.

Looking at the Chargers, Justin Herbert also was in mid-season form on Sunday, throwing for 279 yards and three touchdowns vs. the Raiders, despite missing Keenan Allen for much of the game. However, the ground game for Los Angeles did not meet our expectations with Austin Ekeler, Joshua Kelly and Sony Michel combining for only 119 all-purpose yards and no scores against what should have been a susceptible Raiders run defense.

The Chargers defense looked sharp last week, picking off Derek Carr three times and sacking him five times for a loss of 29 yards, though they had trouble stopping Davante Adams. The Chargers picked off Mahomes in both contests last year and that still didn’t stop the Chiefs from running up the score.

The Los Angeles run defense looked entirely different from last season, limiting the Raiders to only 64 yards on the ground Sunday. They should be able to keep Clyde Edwards-Helaire, Jerrick McKinnon, and Isaiah Pacheco in check.

Defensively, the Chiefs allowed three touchdowns to Kyler Murray on Sunday despite the blowout win. There is certainly an opportunity for the Chargers to put up big points and contribute to a high game total.

This game features a pair of division rivals with two of the top QBs in the league and defenses that can be beaten through the air. Even on short rest, I’m going to bet the over and root for a shootout.

As far as who wins this one, the safest play is to take the Chargers plus the points. I think the hook favors Los Angeles, but the bold play is to take the Chargers on the ML at a generous +155 payout. I like to play for plus money, so I’m going bold and picking the Chargers in an upset. Los Angeles' defense will be the slight difference-maker in this game.

The Pick:

Over 54.5

Chargers ML +155