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NFL Week 5 Odds and Best Picks: Must-Bet Underdogs

Three underdogs offer a great betting opportunity in Week 5.

Week 5 in the NFL features the largest favorites we have seen thus far with 7-of-15 games assigned spreads of seven points or more, including the largest spread of the season at 14.5 points.

Through 64 games, underdogs own a 36-25-2 (59.0 percent) against the spread (ATS) mark, while the under has rewarded bettors with a 37-26-1 (58.7 percent) record.

Can Arizona snap a seven-game SU and ATS home losing streak at State Farm Stadium against the undefeated Eagles?

Will the Falcons keep their perfect 4-0 ATS record intact on the road against Tom Brady and the Buccaneers?

Can Matt Rhule, who is 1-11 SU in his last 12 games as head coach of the Panthers, upset the 49ers?

Will Pittsburgh rookie quarterback Kenny Pickett find a way to keep the Steelers within the 14.5-point spread against a Bills club that is 5-1-1 over their last seven games when listed as double-digit favorites?

With so many questions to be answered, let’s dive into three plays being targeted by respected money in Las Vegas!

New York Jets +3.5

Miami will be without quarterback Tua Tagovailoa (concussion) in their Week 5 AFC East showdown with the Jets. The Dolphins will turn to veteran Teddy Bridgewater to extend their 4-0 ATS mark in their last four trips to MetLife Stadium. In his first game in 2022, Jets quarterback Zach Wilson engineered a late fourth-quarter comeback victory at Pittsburgh. Over his last eight starts, the second-year quarterback has proven to be a solid investment at the window, covering the number in five of those games. This could be a trap spot for a Dolphins club that will be missing their emerging signal-caller.

Seattle +5.5

I never thought I would be typing this, but yes respected money in Las Vegas is backing Geno Smith at the betting window. Smith, who has thrown for 320-plus yards and multiple touchdowns in consecutive weeks, will face an injury-laden Saints club that has lost three consecutive games. Bettors need to monitor the status of New Orleans’ running back Alvin Kamara, wide receiver Michael Thomas and quarterback Jameis Winston who all missed Week 4 against the Vikings. However, with low expectations regarding their game-day status, Seattle as a 5.5-point underdog is too attractive to pass up.

Dallas +4.5

Cooper Rush, who is 3-0 filling in for Dak Prescott, will look to remain unbeaten as a starter in the NFL heading into SoFi Stadium. The Cowboys have been a great road team to back, owning a five-game road winning streak that also finds a corresponding 5-0 ATS mark over that span. The Rams, who were beaten 24-9 on "Monday Night Football," have now fallen to 1-5 ATS over their last six regular-season games dating back to last season. Micah Parsons and Demarcus Lawrence, who lead a ferocious Cowboys pass rush, could have a field day against a Rams offensive line that just allowed Matthew Stafford to be sacked seven times on Monday night against the 49ers.