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NFL Week 6 Odds, Bets and Picks Against the Spread

Three underdogs in Week 6 offer sports bettors a solid wagering opportunity.

Week 6 in the NFL is loaded with intrigue as the high-powered Bills and Chiefs will face off in Arrowhead while the undefeated Eagles will look to increase their hold of the NFC East against the red-hot Cowboys.

Related: NFL Predictions for Every Game in Week 6

Through 80 games, underdogs own a 47-31-2 ATS (60.3 percent) against the spread (ATS) mark, while the under has rewarded bettors with a 46-33-1 (58.2 percent) record.

Over the last 10 meetings, the Colts are 1-8-1 ATS against Jacksonville. Can Indianapolis avenge a Week 2 straight up (SU) and ATS loss to Jacksonville?

Will the Falcons keep their perfect 5-0 ATS record intact at home against Jimmy Garoppolo and the 49ers?

After firing Matt Rhule, can the Panthers who are 1-11 SU in their last 12 games, upset the Rams as 10.5-point road underdogs under interim head coach Steve Wilks?

Will Arizona, who is 6-1 ATS in their last seven games in Seattle, be able to slow down Geno Smith who leads the NFL in completion percentage (75.2 percent)?

After going 2-1 SU and ATS on our three underdog targets last week, let’s dive into Week 6!

New York Jets +7 vs. Packers

Zach Wilson has led the Jets to back-to-back wins since returning from his preseason knee injury. Over his last nine starts, the second-year quarterback has proven to be a solid investment at the betting window covering the spread in six of those games. The Packers are an overtime field goal away against the Patriots from losing consecutive games as heavy favorites. Green Bay, who was upset by the Giants in London, could potentially get swept by New York teams this season. Nevertheless, this is simply too many points to pass up on a Jets club buying into Robert Saleh’s program.

Patriots +3 vs. Browns

The Patriots' defense dominated the Lions in Week 5 shutting out (29-0) one of the best offenses in the NFL. The Browns, who have already lost at home against the Jets and Chargers this season, are 2-6 ATS over their last eight home games. Bill Belichick knows the weaknesses of quarterback Jacoby Brissett after coaching him back in 2016. Expect New England to load the box to try and shut down Nick Chubb and Kareem Hunt, forcing Cleveland to become one-dimensional.

Dallas +6 vs. Eagles

Cooper Rush, who is 4-0 filling in for Dak Prescott, will look to remain unbeaten against NFC East opponents after previously taking down the Giants and Commanders. The Cowboys, who are 6-0 SU and ATS over their last six road games, will try and become the first team to defeat the Eagles (5-0 SU) this season. Dallas owns a three-game winning streak over Philadelphia and a deeper look reveals that the Cowboys are 7-3 SU and ATS in their last 10 showdowns against their NFC East foe.