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DeAndre Hopkins, Christian McCaffrey and Brandon Aiyuk Best Prop Bets and Odds for Monday Night Football

Bettors looking to cash in on Week 11's final game need to check out these 49ers and Cardinals superstars.

The Cardinals and 49ers meet for the first time this season on Monday night at a neutral site.

This prime-time NFC West showdown will kick off from Estadio Azteca in Mexico City. Arizona can begin to claw its way back into the playoff picture with a victory while San Francisco goes for its third consecutive win and looks to gain ground on the division-leading Seahawks, who are on bye this week.

There’s a talented group of skill position players between these two teams, which makes the prop bet market especially intriguing. Below are three props I like for this game.

DeAndre Hopkins Anytime Touchdown Scorer (+163)

In four games back from suspension, Hopkins has four red zone targets and two touchdowns. It doesn’t matter if it’s Kyler Murray or Colt McCoy under center — Arizona’s top option has been hyper-targeted to the tune of 11.5 looks per game. Last week against the Rams he caught 10 of 14 targets for 98 yards but didn’t score. With as many targets and receptions as he’s logged so far, he’s bound to have a scoring opportunity against San Francisco, which is much weaker against the pass than the run. Hopkins has the fourth-best odds to score in this contest, which feels like great value for a player of his caliber. Keep an eye on his status leading up to the game as he is currently questionable with a hamstring injury.

Christian McCaffrey Under 65.5 Rushing Yards (-125)

Since getting to San Francisco, CMC has only topped this total once. To be fair, he barely played in his first game as a 49er and in his second game, he romped for 94 yards. But last week against the Chargers — one of the worst run defenses in the league — he finished with just 38 yards while Elijah Mitchell handled the bulk of the work on the ground and rushed for a game-high 89. Arizona has a top-10 run defense and if McCaffrey isn’t going to get a huge share of volume on the ground (he still caught four passes last week) it’s hard to see him hitting this figure without a chunk play.

Brandon Aiyuk Over 55.5 Receiving Yards (-120)

Aiyuk has gone over this mark in his last five games and he’s cleared it by 25-plus yards in each of his last four. This jump in production has coincided with a higher target share — he’s had six or more targets in each of his last four games after only seeing that many passes come his way twice over his first five. The connection between him and Jimmy Garoppolo has taken off in recent weeks and Arizona, which has a bottom-10 pass defense, is also down Byron Murphy Jr., one of its top defensive backs. This should be another big outing for Aiyuk.