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Week 4 NFL Odds and Best Bets; Road Underdog Will Pull off an Upset

Three expert bets including one road underdog for Week 4 in the NFL.

Week 4 in NFL betting finds a highly competitive board with 10 of 15 games assigned spreads of three points or less.

Through 49 games, underdogs own a 28-19-2 ATS (59.6 percent) against the spread (ATS) mark, while the under has rewarded bettors with a 30-18-1 (62.5 percent) record.

Can the Eagles remain undefeated against the red-hot Jaguars?

Will Las Vegas earn its first win of the season against Russell Wilson and the Broncos?

Will the Ravens, who are 5-0 ATS in their last five games as home underdogs, upset the Buffalo Bills?

With so many questions to be answered, let’s dive into three plays being targeted by respected money in Las Vegas!

Cleveland Browns ML -115

The Falcons are one of three 3-0 ATS teams through three weeks of action. However, in Week 4 they will face the Browns, who own the league’s best rushing attack through three games averaging 190.6 yards per game on the ground. Jacoby Brissett guiding an offense featuring Nick Chubb and Kareem Hunt in the backfield will help the club earn their second consecutive road victory to start the season.

Los Angeles Chargers -5

The Chargers have been hit with a vast amount of injuries on both sides of the ball and will now be without starting offensive tackle Rashawn Slater (bicep) for the season and All-Pro defensive end Joey Bosa (groin) indefinitely. With Justin Herbert nursing injured ribs, look for Los Angeles to pound the ground game against a Houston defense that ranks last against the run, surrendering 202.3 yards per game. The Chargers will be motivated to avenge a 41-29 loss last season to the Texans in Week 16 as 13.5-point home underdogs.

Arizona Cardinals ML +105

Sources in Vegas are expecting that Panthers star running back Christian McCaffrey (thigh) will likely miss Sunday's game against the Cardinals despite getting in his first "limited" practice of the week on Friday. Arizona appears to be catching a Panthers squad that is 3-14 ATS over their last 17 games at the right time. Dating back to 2015, Carolina has dominated the Cardinals posting a 6-0 SU and ATS record. However, like they say, all things must come to an end. If the Panthers are forced to rely upon the league's 30th-ranked offense (276.3 yards per game), without one of the best players in the league, the Cardinals at plus-odds become a strong investment opportunity.