Never bench your studs. Yeah, right. Just because you drafted a running back in the first round, don't think you can just set him in the starting lineup and not have to worry about him falling on his face.
Case in point is Week 1 and Baltimore's Ray Rice. If you're in a non-PPR sit him. If you're in a league without a flex position, sit him. And if you're in a PPR league with a flex position, really consider going somewhere else this week if you have better options/matchups.