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10 College Football Picks Against the Spread for Week 12

Sam Darnold

Sam Darnold

The Week 12 edition of college football’s picks against the spread features predictions for some of Saturday’s biggest games, including Colorado-Washington State, Oklahoma-West Virginia, TCU-Oklahoma State and LSU-Florida. Additionally, conference matchups such as Missouri-Tennessee, Kansas-Texas, Northwestern-Minnesota, and USC-UCLA feature lines or odds that caught our attention for Week 12. Here are 10 predictions or picks against the spread for this weekend's action:

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10 CFB Picks Against the Spread for Week 12

TCU (-4.5) over Oklahoma State

TCU has lost four games, but two came in double overtime and another was by six points to Oklahoma. This is a decent team that is capable of matching Oklahoma State’s high-powered offense.

Related: Predictions for Every College Football Game in Week 12

LSU (-13.5) over Florida

Here’s a crazy stat: Florida has ranked no higher than 10th in the SEC in total offense since the 2009 season. It’s tough to envision the Gators scoring enough to keep this close.

Colorado (-4.5) over Washington State

These two unlikely contenders meet in one of the biggest games of the weekend. Go with the Buffs — and their very good defense — at home.

Missouri (+16) over Tennessee

Winning in Neyland will be a tall task, but don’t be surprised if the Tigers score a bunch of points on Saturday afternoon. Freshman tailback Damarea Crockett is one of the SEC’s more underrated skill players.

Kansas (+24) over Texas

The Jayhawks are still searching for their first win vs. an FBS opponent since the 2014 season. They won’t get it on Saturday, but they might make Texas sweat for a bit.

Northwestern (-1) over Minnesota

Northwestern has quietly turned things around after an 0–2 start. They are 5–3 since, with the losses coming by 11 points to Nebraska, four points to Ohio State and 14 to Wisconsin.

Indiana (+23.5) over Michigan

Michigan will be without quarterback Wilton Speight (we think) for the first time this season. It won’t be a big surprise if the offense struggles a bit.

Oklahoma (-2.5) over West Virginia

Oklahoma has been one of the nation’s top offensive teams in 2016. In league games, quarterback Baker Mayfield is completing 74.9 percent of his passes and averaging 11.5 yards per attempt. No QB is posting better numbers nationally in league games.

Boston College (-7) over Connecticut

Two of the worst offensive teams in the nation will be on display in this regional rivalry. Don’t expect many touchdowns. 

USC (-13) over UCLA

UCLA is 2–5 in the Pac-12, with its two wins coming over Arizona and Oregon State — the two worst teams in the league. 

Last week: 4-6

Season: 38-41-1