The Week 4 edition of college football’s picks against the spread features predictions for some of Saturday’s biggest games, including Michigan State-Wisconsin, Florida-Tennessee and Texas A&M-Arkansas. Additionally, conference matchups such as LSU-Auburn, Ole Miss-Georgia and Colorado-Oregon feature lines or odds that caught our attention for Week 4. Here are 10 predictions or picks against the spread for this weekend's action:
10 CFB Picks Against the Spread for Week 4
Michigan State (-5) over Wisconsin
Louisville and Ohio State stole the headlines with their big wins last week, but Michigan State also made a huge statement with a 36–28 victory at Notre Dame (as an 8-point dog). This is a tough spot for Wisconsin quarterback Alex Hornibrook, making his first career start.
Texas A&M (-5.5) over Arkansas
Texas A&M is quietly off to a great start in 2016, with an overtime win over UCLA at home and a workman-like 29–16 victory at Auburn. The Aggies are getting it done in very un-Sumlin-like fashion — running the ball and playing great defense.
Florida (+6.5) over Tennessee
Tennessee is extremely banged up on defense, which could make life a bit easier for Florida quarterback Austin Appleby. The key matchup in the game, however, is Tennessee’s offensive line vs. Florida’s defensive front. Huge advantage to the Gators.
LSU (-3.5) over Auburn
LSU dominated Mississippi State for three-plus quarters before allowing the Bulldogs to make things interesting late. Expect heavy doses of Leonard Fournette mixed in with some timely play action from Danny Etling & Co.
Ole Miss (-7) over Georgia
The Rebels will have to show some mental toughness after losing a 21-point lead for the second time in three games. Hugh Freeze has proven he can keep a team together; last year, the Rebels bounced back from a loss to Memphis by beating Texas A&M and Auburn, and then responded from the heartbreaker vs. Arkansas by closing the season with wins over LSU, Mississippi State and Oklahoma State.
Wake Forest (+7.5) over Indiana
The Demon Deacons are a bit banged up, but this program has taken a big step forward in 2016. Wake ranks third in the ACC in total defense and has allowed a total of 17 points in two games vs. FBS foes.
Colorado (+10.5) over Oregon
I’d feel a lot better about this pick if Colorado quarterback Sefo Liufau was 100 percent after injuring his ankle against Michigan. The Buffs, at full strength, have been very, very good on offense this season. Oregon is dealing some significant injuries and is coming off a difficult loss at Nebraska.
Kentucky (-2.5) over South Carolina
Kentucky quarterback Drew Barker is out with a back injury. But that’s necessarily a bad thing. Stephen Johnson, a first-year junior college transfer, came off the bench and threw for 210 yards and threw scores vs. New Mexico State.
Stanford (-3) over UCLA
Stanford has been very business-like in its first two games, beating Kansas State and USC with a strong running game and efficient passing attack. Expect more of the same Saturday against a UCLA team that has yet to click offensively.
Washington (-11) at Arizona
Washington takes its show on the road after three lopsided win over inferior opponents in Seattle. The Huskies are clearly the better team and should have little trouble with Arizona — even in Tucson.