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10 College Football Picks Against the Spread for Week 5

Skyler Howard

Skyler Howard

The Week 5 edition of college football’s picks against the spread features predictions for some of Saturday’s biggest games, including Louisville-Clemson, Washington-Stanford and Michigan-Wisconsin. Additionally, conference matchups such as Tennessee-Georgia, Wake Forest-NC State and Northwestern-Iowa feature lines or odds that caught our attention for Week 5. Here are 10 predictions or picks against the spread for this weekend's action:

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10 College Football Picks Against the Spread for Week 5

Louisville (-2) at Clemson

It tells you just how impressive Louisville has been through the first month of the season that the Cards are favored on the road against a team that played in the national title game last year. I’m drinking the Cardinal Kool-Aid.

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Duke (-3.5) over Virginia

After averaging 383 yards and 17 points in losses to Wake Forest and Northwestern, Duke erupted for 498 yards and 38 points in its win at Notre Dame. We know the Irish have major issues on defense, but we also believe that Daniel Jones and Blue Devils’ offense is starting to figure things out a bit. 

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Related: Predictions for Every Game in Week 5

Wake Forest (+11) over NC State

This line seems way to high. Wake Forest is 4–0 and already has two road wins (Duke, Indiana) on its résumé. There’s serious pressure on NC State, which has yet to beat a quality opponent (that’s nothing new) and lost at East Carolina.

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Tennessee (-3.5) over Georgia

This has all the makings of a trap game for Tennessee, fresh off its breakthrough win over Florida. But the Vols are simply the better team.

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Missouri (+13) over LSU

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LSU figures to be re-energized under interim head coach Ed Orgeron, but there doesn’t appear to be a quick fix for the Tigers’ offense. Missouri will score enough to make this interesting.

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Washington (-3) over Stanford

Washington dominated three inferior opponents at home before winning in overtime last week at Arizona. Stanford has been outstanding on defense against a schedule that has featured three games vs. Power 5 opponents. The Cardinal are the more seasoned team, but UW is ready to break through under Chris Petersen.

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Michigan (-10.5) over Wisconsin

Wisconsin shocked the college football world with its surprisingly easy win in East Lansing last week. Winning in the state of Michigan once again will be a huge challenge. Here’s my favorite Michigan stat: Opponents are only 6-of-50 on third downs.

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Northwestern (+13) over Iowa

Northwestern has been a disappointment in 2016 with a 1–3 record, but this is not a bad team. Iowa has struggled offensively the last two weeks, with 231 yards vs. North Dakota State and 355 vs. Rutgers.

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West Virginia (-3.5) over Kansas State

West Virginia is quietly 3–0, with solid wins over Missouri and BYU. Could this team be a contender in the wide-open Big 12? Probably not, but the Mountaineers should win this game at home.

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Memphis (+14.5) over Ole Miss

Memphis has won its last two games (over Kansas and Bowling Green) by a combined score of 120–10. The Tigers clearly can score. Can they slow down Ole Miss? The guess here is just enough to cover the 14.5-point spread.

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Last week: 6–4