The Week 6 edition of college football’s picks against the spread features predictions for some of Saturday’s biggest games, including Tennessee-Texas A&M, Florida State-Miami and Alabama-Arkansas. Additionally, conference matchups such as Washington-Oregon, Texas-Oklahoma and North Carolina-Virginia Tech feature lines or odds that caught our attention for Week 6. Here are 10 predictions or picks against the spread for this weekend's action:
10 College Football Picks Against the Spread for Week 6
Oregon (+9) over Washington
I’ve been on board the Washington bandwagon since the end of the 2016 season, but this line seems a bit high considering this game is in Eugene. Also, the Huskies have some mental baggage to shed: Oregon has won 12 straight in this series.
Florida State (+3) over Miami
All signs point to Miami — 4–0 under first-year head coach Mark Richt — in this one, but Florida State is too good (and has too much pride) to lose a third game this early in the season.
Alabama (-14) over Arkansas
Alabama struggled in its last trip to Fayetteville, beating the Hogs 14–13 at Razorback Stadium in 2014. The Tide didn’t struggle in its previous visit, winning 52–0 in 2012. This one will be close for a while … until it’s not close.
Texas (+10) over Oklahoma
Oklahoma is clearly the better team, but strange things happen in the Red River Shootout — especially when it’s an unranked Texas vs. ranked Oklahoma. Take the Sooners to win, but not by double digits.
Penn State (+1.5) over Maryland
Not many Nittany Lions fans envisioned a scenario in which their team, in James Franklin’s third season, would be a home underdog to Maryland. Penn State has its issues, but the Lions will find a way to survive at Beaver Stadium.
Duke (-5) over Army
Army was off to a 3–0 start before an inexplicable loss in overtime to Buffalo two weeks ago. Duke has one win over an FBS team — at Notre Dame. The Devils are simply better.
North Carolina (-1.5) over Virginia Tech
This line opened up at 5.5 but settled in at 1.5, in favor of the home-standing Tar Heels. Mitch Trubisky, who has yet to throw an interception this season, and the North Carolina offense are averaging 7.5 yards per play through five games.
Minnesota (-1.5) over Iowa
One of the big mysteries in college football this season: Iowa ranks 11th in the Big Ten in rushing with 143.2 yards per game, including an anemic 56.5 in its two losses.
Texas A&M (-7) over Tennessee
We’ve been teased in the past by fast-starting teams at A&M in the Kevin Sumlin era, but this group appears to be different — thanks to a strong running game and an improved defense. It’s not wise to pick against Tennessee, but this is a really tough spot for the Vols.
USC (-4.5) over Colorado
Colorado (2–0 in the Pac-12) has been the most surprising team in the nation this season. USC, on the other hand, is a disappointment at 2–3. But the Trojans are coming of a 41–20 win over Arizona State — a game in which they played up to their potential on both sides of the ball.
Last week: 2–8