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College Fantasy Football: Week 4 DFS Picks Saturday (Sept. 25) Games

Let our fantasy experts help you pick a great college fantasy football lineup
Sam Howell, North Carolina Tar Heels Football

Sam Howell, North Carolina Tar Heels Football

Week 4 of the 2021 college football season continues on Saturday, Sept. 25. That means it’s time to pick your optimal DraftKings college football fantasy lineup. Fortunately, our college football fantasy experts are ready to help. Players from 12 matchups are available to be selected on DraftKings for the first slate on Saturday, including Missouri-Boston College, LSU-Mississippi State, Texas Tech-Texas and SMU-TCU. The afternoon lineups can be filled by five matchups, including Louisville-Florida State, Texas A&M-Arkansas and Clemson-NC State. The first night section features seven contests to choose from, including Kentucky-South Carolina, Nebraska-Michigan State, Tennessee-Florida and West Virginia-Oklahoma. The final slate features four contests to make selections from, including USF-BYU, Arizona-Oregon, Oregon State-USC and Colorado-Arizona State.

A better picture of fantasy value for all 130 teams is starting to emerge in Week 4. Here’s what our best Week 4 (Sept. 25) college fantasy football DFS lineup looks like for Saturday's matchups:

College Fantasy Football DFS Picks

Saturday DFS Slate (Noon ET - 12 games) 

QB: Malik Cunningham, Louisville (at Florida State - $8,800)

RB: Zach Evans, TCU (vs. SMU - $6,200)

RB: Blake Corum, Michigan (vs. Rutgers - $6,700)

WR: Jaden Walley, Mississippi State (vs. LSU - $4,800)

WR: Khalil Shakir, Boise State (at Utah State - $7,400)

WR: Reggie Roberson Jr., SMU (at TCU - $4,500)

Flex: Xavier Worthy, Texas (vs. Texas Tech – $4,700)

S-Flex: Tyler Badie, Missouri (at Boston College - $6,900)

Saturday DFS Slate (3:30 p.m. ET - 5 games) 

QB: Malik Cunningham, Louisville (at Florida State - $8,800)

RB: Blake Corum, Michigan (vs. Rutgers - $6,700)

RB: Will Shipley, Clemson (at NC State - $5,800)

WR: Cornelius Johnson, Michigan (vs. Rutgers - $5,200)

WR: Marshon Ford, Louisville (at Florida State - $5,500)

WR: Justyn Ross, Clemson (at NC State - $6,300)

Flex: Breece Hall, Iowa State (at Baylor - $7,000)

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S-Flex: Treshaun Ward, Florida State (vs. Louisville - $4,300)

Saturday DFS Slate (7 p.m. ET - 7 games) 

QB: Sam Howell, North Carolina (at Georgia Tech)- $9,000)

RB: Malik Davis, Florida (vs. Tennessee - $5,400)

RB: Alton McCaskill, Houston (vs. Navy - $3,500)

WR: Wan’Dale Robinson, Kentucky (at South Carolina - $6,000)

WR: Josh Downs, North Carolina (vs. Georgia Tech – $5,600)

WR: Kyric McGowan, Georgia Tech (vs. North Carolina – $5,600)

Flex: Mario Williams, Oklahoma (vs. West Virginia - $4,900)

S-Flex: Kenneth Walker, Michigan State (vs. Nebraska – $7,200)

Saturday DFS Slate (10:15 p.m. ET - 4 games) 

QB: Kedon Slovis, USC (vs. Oregon State - $8,800)

RB: Tyler Allgeier, BYU (vs. USF - $6,500)

RB: CJ Verdell, Oregon (vs. Arizona - $7,800)

WR: Stanley Berryhill III, Arizona (at Oregon - $6,300)

WR: Trevon Bradford, Oregon State (at USC - $5,100)

WR: Xavier Weaver, USF (at BYU - $4,900)

Flex: Gary Bryant, USC (vs. Oregon State - $5,700)

S-Flex: Daniyel Ngata, Arizona State (vs. Colorado - $4,700)

Podcast: Complete Week 4 Preview and Predictions + Picks Against the Spread