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5 College Football Picks Against the Spread (ATS) for Week 1

College football is back! After getting some good appetizers in Week 0, the sport you love is back with a vengeance in Week 1 with a full expanded weekend of games to break in the new season. And there are some good matchups that will carry early playoff hype with Ohio State hosting Notre Dame and defending Pac-12 champion Utah traveling into SEC country to take on the Florida Gators.

Related: College Football Predictions for Every Game in Week 1

And, of course, part of the fun of college football is placing a few bucks on the point spread. This weekend can be one of the toughest to predict given it is the start of the new season. So let's dive right in and see what games are worth getting excited for in Week 1.

Note: All times are ET and all games are on Saturday, Sept. 3 unless otherwise noted.

No. 24 Houston (-4) at UTSA, 3:30 p.m.

This could be a big year for the Houston Cougars, but they will be in for a bit of a battle against UTSA in a road opener. But a strong second half to put the game away will help Houston manage to cover the spread. Houston 33, UTSA 23

Florida (+3) vs. No. 7 Utah, 7 p.m.

Utah may be the class of the Pac-12, but the Utes will have trouble leaving Gainesville with a win over the Gators. Yes, Florida is in a bit of a rebuild under new head coach Billy Napier, and the Utes are about as solid and stabilized as programs come these days, but Florida will find a way to scramble to a season-opening upset. Florida 26, Utah 20

No. 20 Kentucky (-15.5) vs. Miami (Ohio), 7 p.m.

The Will Levis show will be electrifying and too much for the RedHawks to slow down. Miami stands no chance on the road at Lexington, and Levis goes off at their expense in a romp. Kentucky 42, Miami (Ohio) 17

No. 2 Ohio State (-17) vs. No. 5 Notre Dame, 7:30 p.m.

Notre Dame may feel disrespected with this line, but the Buckeyes are for real. Even more dangerous? Ohio State is on a mission this season after missing out on a Big Ten title and a spot in the playoff. The Buckeyes, fueled by the passing combination of C.J. Stroud and Jaxon Smith-Njigba are too powerful for the visiting Irish. Ohio State 34, Notre Dame 16

LSU (-3) vs. Florida State, Sunday, Sept. 4, 7:30 p.m.

Brian Kelly makes his LSU coaching debut against Florida State on Sunday night, and it should go down as a win. The Seminoles will show some improvement this season, but the Tigers will be able to make adjustments and get by with their defense. LSU 26, Florida State 17

Podcast: Week 1 Preview and Predictions + Betting and Picks Against the Spread

— Written by Kevin McGuire, who is part of the Athlon Contributor Network. Follow him on Twitter @KevinOnCFB, on Instagram, on TikTok, and Like him on Facebook.