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5 College Football Picks Against the Spread (ATS) for Week 10

Sam Hartman, Wake Forest Demon Deacons Football

Sam Hartman and undefeated Wake Forest are slight underdogs heading into Saturday's game in Chapel Hill against North Carolina

The calendar has turned to November, which means the college football regular season has reached the home stretch. The initial College Football Playoff Rankings came out earlier this week, just another signal of what's at stake in these remaining games.

Related: Expert Predictions for Every College Football Game in Week 10

And speaking of games, there are still plenty left to pick against the spread, including a couple this weekend featuring ranked teams that are underdogs on the road.

Note: All times are ET and all games are on Saturday, Nov. 6.

No. 9 Wake Forest (+2.5) at North Carolina, 12 p.m.

Yes, Wake Forest's defense leaves plenty to be desired (gave up 56 points and nearly 600 yards to Army) and North Carolina has a lot of firepower, led by quarterback Sam Howell. However, the Tar Heels have yet to answer the bell this season (just one win against a team that's above .500) and I don't see that changing, even at home in what will likely be an entertaining, high-scoring, non-conference (that's not a typo) affair. Wake Forest 41, North Carolina 35

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No. 12 Baylor (-6.5) at TCU, 3:30 p.m.

TCU has lost three in a row and just parted ways with the head coach who has been in charge of the program for two decades. So there's no real reason to expect the Horned Frogs to do much else but play out the string, especially against a Baylor team that has its sights on a spot in the Big 12 title game. Baylor 31, TCU 17

No. 17 Mississippi State (+5) at Arkansas, 4 p.m.

One of these teams is currently in the basement of the SEC West having lost their last three conference games by a combined 53 points. The other team has won two in a row and boasts the nation's fourth-ranked passing offense. Why the former is favored over the latter is the real mystery here. Mississippi State 31, Arkansas 24

No. 23 Fresno State (-5) vs. Boise State, 7 p.m.

Most years it would be risky picking against Boise State, even on the road. But this is not most years as the 2021 edition of the Broncos can't run the ball or stop anyone from doing it against them. That's not a good combination headed into a matchup with the Mountain West's top offense. Fresno State 38, Boise State 24

Oregon State (-10.5) at Colorado, 7 p.m.

Oregon State is one win away from bowl eligibility and still in the conversation to win the Pac-12 North. The Beavers have had their share of issues winning on the road, but Colorado has yet to beat an FBS team that has won a game this season. Beavers bludgeon Buffaloes in Boulder. (Try saying that five times fast.) Oregon State 35, Colorado 13

Last Week: 2-3
Season: 24-25

Podcast: Week 10 Predictions, CFB Playoff Rankings Debate and Conference Expansion News