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5 College Football Picks Against the Spread (ATS) for Week 13

Ohio State enters massive showdown with fellow undefeated Michigan as more than a touchdown favorite.

The finale of the 2022 college football regular season is upon us as division races and conference championship game matchups from coast to coast will be decided as we stuff our faces with leftover turkey and pumpkin pie this Thanksgiving weekend. The culmination of the regular season gives us one final chance to run the table and come out ahead in our weekly picks against the spread.

Related: College Football Predictions for Every Game in Week 13

It has been a tricky season picking games but the pursuit of a 5-0 week continues this week with a good mix of rivalry games with a lot riding on them. From Ohio State-Michigan to Washington-Washington State, we have a full day of intense rivalry games to be thankful for as we look forward to conference championship weekend.

Here are the games on the radar for our picks this weekend.

Note: College Football Playoff ranking is reflected below. All times are ET and all games are scheduled for Saturday, Nov. 26.

No. 3 Michigan (+7.5) at No. 2 Ohio State

12 p.m. on FOX, live stream on fuboTV (Start your free trial)

The game of the year in the Big Ten has more than just a spot in the conference championship game on the line. The College Football Playoff implications riding on the outcome of this game are not to be overlooked as Ohio State and Michigan renew their rivalry once more. The Buckeyes are looking for revenge, and they will get it, but the Wolverines' defense keeps this thing close enough. Ohio State 33, Michigan 27

South Carolina (+14.5) at No. 8 Clemson

12 p.m. on ABC, live stream on fuboTV (Start your free trial)

Ride that wave of confidence South Corlina exhibited last week with its monster game against Tennessee into this week's rivalry game at Clemson. The Tigers are still holding out hope for an outside shot at the playoff but the Gamecocks are suddenly as dangerous as they come. Clemson 33, South Carolina 26

No. 4 TCU (-10) vs. Iowa State

4 p.m. on FOX, live stream on fuboTV (Start your free trial)

The Horned Frogs had a close call last week at Baylor but they should be able to take care of things a bit easier at home this weekend against Iowa State. Still holding on to that fourth College Football Playoff spot, TCU can't afford another close call. TCU 27, Iowa State 13

No. 15 Notre Dame (+5.5) at No. 6 USC

7:30 p.m. on ABC, live stream on fuboTV (Start your free trial)

The Fighting Irish have come on strong at the right time. After some early-season struggles, Notre Dame has figured things out and is prepared to give USC all it can handle. Expect a close one out on the west coast as the Irish give USC a serious scare. USC 34, Notre Dame 32

No. 13 Washington (-2.0) at Washington State

10:30 p.m. on ESPN, live stream on fuboTV (Start your free trial)

The Apple Cup is always capable of serving up some wild drama, and this year should be no exception. Washington could have a shot at the Pac-12 Championship Game by the time this one is played, so expect the Huskies to let Michael Penix Jr. run (and throw) wild. Washington 30, Washington State 26

Last Week: 2-3
Season: 25-29-1

Podcast: Week 13 Preview, Predictions, Picks Against the Spread, Breakdown of the Latest CFB Playoff Rankings, and Coaching News and Rumors

Written by Kevin McGuire, who is part of the Athlon Contributor Network. Follow him on Twitter @KevinOnCFB, on Instagram, and like him on Facebook.