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6 College Football Picks Against the Spread (ATS) for Week 2

6 College Football Picks Against the Spread (ATS) for Week 2

6 College Football Picks Against the Spread (ATS) for Week 2

If any lesson could be learned from Week 1 of the college football season, it is that there are going to be some not-so-perfect performances as teams return to game action. That meant picking against the spread was a dangerous activity. You can expect that trend to carry over to Week 2 as the ACC and Big 12 begin sending teams out to the football field. Among the teams in action this week are ACC contenders Clemson and North Carolina, and each are hefty favorites in their respective openers.

Also on the schedule this week is Army, who may actually be the safest bet on the board this week after their showing last week. Here's a look at some of the spreads you should be paying attention to this weekend around college football.

Syracuse (+22) at North Carolina

Sam Howell and the Tar Heels have high expectations for the 2020 season, and it begins at home against a Syracuse team looking to rebound after a disappointing 2019 season. UNC should win this game comfortably, with Howell getting his stats, but do not be surprised if the Orange hang around and cut into the deficit to get the late cover. North Carolina 34, Syracuse 17

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Army (-19) vs. ULM

Army overpowered their Week 1 opponent last week, blasting Middle Tennessee 42-0. The Black Knights have two things in their favor here; they have already played a game and they have that tiring option run game that wears opponents down. Don't count on much of a fight from ULM, who has already undergone a change at defensive coordinator in the week leading up to their season opener. Army 31, ULM 10

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Louisville (-12) vs. WKU

If there is one thing you can trust in a Scott Satterfield team, they will have a pretty solid record against the spread. That should continue to be the case this season as Louisville continues to improve. The Cardinals could be in for a pretty big year, and quarterback Micale Cunningham should put up some big numbers in his season debut. Louisville 31, WKU 17

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College football rankings: Louisville

Kansas (-7) vs. Coastal Carolina

Picking Kansas as a favorite? It doesn't happen often, so when it pops up you just have to roll with it. Les Miles has been doing a good job starting to build a foundation for the Jayhawks though. How quickly Kansas can knock off rust from the offseason will be key, but winning this game by two scores is not at all off the table.

College Football Rankings: Kansas

Duke (+20) at Notre Dame

Notre Dame's first official ACC conference game in program history is a favorable draw, but don’t be shocked if Duke manages to keep things somewhat respectable in South Bend. The Irish just have too much firepower to be in any real danger against the Blue Devils, but Duke will be scrappy enough to keep things close to cover the nearly three-touchdown spread. Notre Dame 30, Duke 17

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Clemson (-33) at Wake Forest

Going with a 30-point favorite on the road in a season-opening conference game is generally not a wise move, especially given the uncertainty of how well things will go coming off a disruptive offseason. Then again, doing so feels like a pretty safe move when Trevor Lawrence is the quarterback. Expect Clemson to set the tone for their season with authority. Clemson 49, Wake Forest 10

College Football Top 25 Rankings: Clemson

— Written by Kevin McGuire, who is part of the Athlon Contributor Network. Follow him on Patreon, on Twitter @KevinOnCFB, on Instagram, and Like him on Facebook.