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5 College Football Picks Against the Spread (ATS) for Week 4

Clemson, Oregon, Utah all favored on the road for their conference matchups on Saturday.

Another weekend of college football presents some opportunities to take advantage of some big favorites against the spread. There are some lopsided lines that could be tricky territory for most, but there are definitely some teams you should feel confident in rolling with in Week 4.

Related: College Football Predictions for Every Game in Week 4

We suffered another tough weekend by placing too much faith in Nebraska coming out fired up to cover a big spread at home as an underdog against Oklahoma and expecting a little too much from BYU and Texas Tech as road underdogs. So this week, no road underdogs will be chosen after being bitten too many times already this season.

Here is a look at this week's picks as we search for a clean 5-0 mark for the weekend.

Note: All times are ET and all games are scheduled for Saturday, Sept. 24.

No. 5 Clemson (-7) at No. 21 Wake Forest

12 p.m. on ABC, live stream on fuboTV (Start your free trial)

Is Clemson for real? We should get the first glimpse of that this weekend as the Tigers hit the road to face Wake Forest. The Demon Deacons know the barometer for success in the ACC still comes against Clemson, and they have not played their best against the Tigers. Expect a good fight from Wake Forest, but Clemson puts the game away in the second half with some soul-crushing plays. Clemson 30, Wake Forest 18

Related: College Football Upset Watch for Week 4

No. 15 Oregon (-6.5) at Washington State

4 p.m. on FOX, live stream on fuboTV (Start your free trial)

Oregon beat up on BYU last weekend in Eugene and made some forget about how rough the season opener was for the Ducks. Maybe Georgia's just that darn good? In any event, going on the road to face the Cougars could get hairy, but the Ducks find a way to come out on top by at least a touchdown. Oregon 27, Washington State 20

No. 10 Arkansas (+2) vs. No. 23 Texas A&M

7 p.m. on ESPN, live stream on fuboTV (Start your free trial)

There seems to be a lot of momentum riding on Texas A&M after their confidence-boosting win last week against Miami, but don't sleep on the Razorbacks. Arkansas has looked incredibly solid to start the season and could flex against the Aggies in Jerry World. Arkansas 26, Texas A&M 24

No. 3 Ohio State (-19) vs. Wisconsin

7:30 p.m. on ABC, live stream on fuboTV (Start your free trial)

The Big Ten opener for the Buckeyes and Badgers could be a bit of a bummer for Wisconsin. Ohio State has exploded on offense the past couple of weeks and should carry that over against its biggest defensive test since Notre Dame in the season opener. Wisconsin won't have the firepower to keep things too close for too long as Ohio State puts this thing on cruise control in the second half. Ohio State 38, Wisconsin 17

No. 13 Utah (-15.5) at Arizona State

10:30 p.m. on ESPN, live stream on fuboTV (Start your free trial)

Consider this a lesson learned from last week by expecting too much of Nebraska after a coaching change. We're not making the same mistake again after Arizona State fired Herm Edwards. We can probably rely on Utah to keep things under control from start to finish in this Pac-12 late-night matchup. Utah 34, Arizona State 10

Last Week: 2-3
Season: 6-9

Podcast: Week 4 Preview, Predictions and Picks Against the Spread

— Written by Kevin McGuire, who is part of the Athlon Contributor Network. Follow him on Twitter @KevinOnCFB, on Instagram, on TikTok, and Like him on Facebook.