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College Football Picks: Expert Predictions for Every Game in Week 1

College football's Week 1 slate for the 2022 season features 83 games, and our NCAA experts are ready with their predictions and picks.

Related: Ranking All 83 College Football Games in Week 1

The Week 1 action begins on Thursday night with 16 games, including Penn State-Purdue, West Virginia-Pitt and Central Michigan-Oklahoma State. Eight matchups are slated for Friday, with Virginia Tech-Old Dominion, Illinois-Indiana and TCU-Colorado as the top contests. The first wave of games on Saturday features Sam Houston-Texas A&M, Colorado State-Michigan, NC State-East Carolina and North Carolina-Appalachian State. The afternoon window includes a high-profile showdown between Oregon and Georgia in Atlanta, along with Cincinnati-Arkansas, Houston-UTSA and BYU-USF. The first night slate includes Utah-Florida, Utah State-Alabama, Notre Dame-Ohio State and Louisville-Syracuse. The late-night window features Boise State-Oregon State and Kent State-Washington. Florida State and LSU meet in New Orleans on Sunday, while Clemson and Georgia Tech match up on Monday night in Atlanta.

Each week, Athlon Sports’ editors will pick every game in the FBS ranks. Follow us on Twitter: (@AthlonSports)

Michael Mayer, Notre Dame Fighting Irish Football

College Football Picks: Expert Predictions for Every Game in Week 1

Steven LassanMark RossBen Weinrib

Penn State at Purdue (Thurs.)

Penn State

Penn State

Penn State

Central Michigan at Oklahoma State (Thurs.)

Oklahoma State

Oklahoma State

Oklahoma State

VMI at Wake Forest (Thurs.)

Wake Forest

Wake Forest

Wake Forest

Saint Francis (Pa.) at Akron (Thurs.)

Akron

Akron

Akron

Ball State at Tennessee (Thurs.)

Tennessee

Tennessee

Tennessee

South Carolina State at UCF (Thurs.)

UCF

UCF

UCF

Bryant at FIU (Thurs.)

FIU

FIU

FIU

LIU at Toledo (Thurs.)

Toledo

Toledo

Toledo

Alabama A&M at UAB (Thurs.)

UAB

UAB

UAB

Louisiana Tech at Missouri (Thurs.)

Missouri

Missouri

Missouri

Eastern Illinois at Northern Illinois (Thurs.)

Northern Illinois

Northern Illinois

Northern Illinois

New Mexico State at Minnesota (Thurs.)

Minnesota

Minnesota

Minnesota

Northern Arizona at Arizona State (Thurs.)

Arizona State

Arizona State

Arizona State

Cal Poly at Fresno State (Thurs.)

Fresno State

Fresno State

Fresno State

Portland State at San Jose State (Thurs.)

San Jose State

San Jose State

San Jose State

Western Michigan at Michigan State (Fri.)

Michigan State

Michigan State

Michigan State

Virginia Tech at Old Dominion (Fri.)

Virginia Tech

Virginia Tech

Virginia Tech

Eastern Kentucky at Eastern Michigan (Fri.)

EMU

EMU

EMU

William & Mary at Charlotte (Fri.)

Charlotte

Charlotte

Charlotte

Temple at Duke (Fri.)

Duke

Duke

Duke

Illinois at Indiana (Fri.)

Illinois

Illinois

Illinois

Tennessee Tech at Kansas (Fri.)

Kansas

Kansas

Kansas

TCU at Colorado (Fri.)

TCU

TCU

TCU

Sam Houston at Texas A&M

Texas A&M

Texas A&M

Texas A&M

Colorado State at Michigan

Michigan

Michigan

Michigan

NC State at East Carolina

NC State

NC State

NC State

North Carolina at Appalachian State

North Carolina

App State

North Carolina

South Dakota State at Iowa

Iowa

Iowa

Iowa

Rutgers at Boston College

Boston College

Boston College

Rutgers

Buffalo at Maryland

Maryland

Maryland

Maryland

Delaware at Navy

Navy

Navy

Navy

Central Connecticut at UConn

UConn

UConn

UConn

Richmond at Virginia

Virginia

Virginia

Virginia

Northern Iowa at Air Force

Air Force

Air Force

Air Force

SE Missouri at Iowa State

Iowa State

Iowa State

Iowa State

Bowling Green at UCLA

UCLA

UCLA

UCLA

UTEP at Oklahoma

Oklahoma

Oklahoma

Oklahoma

Bethune-Cookman at Miami

Miami

Miami

Miami

Houston at UTSA

Houston

Houston

Houston

Arizona at San Diego State

San Diego State

San Diego State

San Diego State

North Dakota at Nebraska

Nebraska

Nebraska

Nebraska

Norfolk State at Marshall

Marshall

Marshall

Marshall

Tulsa at Wyoming

Tulsa

Tulsa

Tulsa

Troy at Ole Miss

Ole Miss

Ole Miss

Ole Miss

BYU at USF

BYU

BYU

BYU

UC Davis at California

California

California

California

Nicholls at South Alabama

South Alabama

South Alabama

South Alabama

Texas State at Nevada

Texas State

Nevada

Nevada

Rice at USC

USC

USC

USC

Middle Tennessee at James Madison

James Madison

JMU

JMU

Florida Atlantic at Ohio

FAU

FAU

FAU

Morgan State at Georgia Southern

Ga. Southern

Ga. Southern

Ga. Southern

UAlbany at Baylor

Baylor

Baylor

Baylor

Illinois State at Wisconsin

Wisconsin

Wisconsin

Wisconsin

Miami (Ohio) at Kentucky

Kentucky

Kentucky

Kentucky

Army at Coastal Carolina

Coastal Carolina

Coastal Carolina

Coastal Carolina

South Dakota at Kansas State

Kansas State

Kansas State

Kansas State

Mercer at Auburn

Auburn

Auburn

Auburn

Elon at Vanderbilt

Vanderbilt

Vanderbilt

Vanderbilt

Liberty at Southern Miss

Liberty

Liberty

Liberty

UMass at Tulane

Tulane

Tulane

Tulane

SE Louisiana at Louisiana

Louisiana

Louisiana

Louisiana

Grambling at Arkansas State

Arkansas State

Arkansas State

Arkansas State

Utah State at Alabama

Alabama

Alabama

Alabama

Memphis at Mississippi State

Mississippi State

Mississippi State

Mississippi State

Georgia State at South Carolina

South Carolina

South Carolina

South Carolina

SMU at North Texas

SMU

SMU

SMU

ULM at Texas

Texas

Texas

Texas

Louisville at Syracuse

Louisville

Louisville

Louisville

Murray State at Texas Tech

Texas Tech

Texas Tech

Texas Tech

Maine at New Mexico

New Mexico

Maine

New Mexico

Colgate at Stanford

Stanford

Stanford

Stanford

Idaho at Washington State

Washington State

Washington State

Washington State

Boise State at Oregon State

Oregon State

Oregon State

Oregon State

Kent State at Washington

Washington

Washington

Washington

WKU at Hawaii

WKU

WKU

WKU

Clemson at Georgia Tech (Mon.)

Clemson

Clemson

Clemson

West Virginia at Pitt (Thurs.)

Pitt

Pitt

Pitt

Florida State vs. LSU (New Orleans) (Sun.)

LSU

LSU

LSU

Cincinnati at Arkansas

Arkansas

Arkansas

Arkansas

Utah at Florida

Utah

Utah

Utah

Oregon vs. Georgia (Atlanta)

Georgia

Georgia

Georgia

Notre Dame at Ohio State

Ohio State

Ohio State

Ohio State

Podcast: Complete Week 1 Preview and Predictions + Picks Against the Spread