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College Football Picks: Expert Predictions for Every Game in Week 10

College football's Week 10 slate for the 2022 season features 60 total games, and our NCAA experts are ready with their predictions and picks.

The Week 10 slate got off to an early start with a pair of MAC games on Tuesday night (those predictions were included in last week's table). There will be two more on Wednesday (Central Michigan-Northern Illinois, Western Michigan-Bowling Green), as well as a pair of games on Thursday (UTEP-Rice, Appalachian State-Coastal Carolina). Then it's a Friday tripleheader of UMass-UConn, Duke-Boston College, and some Pac-12 After Dark action between Oregon State and Washington.

On Saturday, Air Force and Army get things started a little earlier in Arlington, Texas, followed by a 12 p.m. ET slate of games that includes Ohio State-Northwestern, Texas Tech-TCU, North Carolina-Virginia, Minnesota-Nebraska, and Florida-Texas A&M. The mid-afternoon slate is highlighted by the huge No. 1 vs. No. 2 (according to the initial College Football Playoff rankings) showdown between Tennessee and Georgia. Other matchups in this window include Oregon-Colorado, Penn State-Indiana, Michigan State-Illinois, Oklahoma State-Kansas, Syracuse-Pitt, Liberty-Arkansas, UCF-Memphis, and Baylor-Oklahoma. That evening, Alabama at LSU and Clemson at Notre Dame headline the first wave, which also includes Texas-Kansas State, Florida State-Miami, BYU-Boise State, Michigan-Rutgers, and Wake Forest-NC State. The busy day of action concludes with California-USC, UCLA-Arizona State, Hawaii-Fresno State, and Colorado State-San Jose State.

Each week, Athlon Sports’ editors will pick every game in the FBS ranks. Follow us on Twitter: (@AthlonSports)

College Football Picks: Expert Predictions for Every Game in Week 10

Steven LassanMark RossBen Weinrib

Central Michigan at Northern Illinois (Wed.)

Northern Illinois

Northern Illinois

Northern Illinois

Western Michigan at Bowling Green (Wed.)

Bowling Green

Bowling Green

Bowling Green

UTEP at Rice (Thurs.)

UTEP

UTEP

Rice

Appalachian State at Coastal Carolina (Thurs.)

Appalachian State

Appalachian State

Appalachian State

UMass at UConn (Fri.)

UConn

UConn

UConn

Duke at Boston College (Fri.)

Duke

Duke

Duke

No. 24 Oregon State at Washington (Fri.)

Washington

Washington

Washington

Air Force vs. Army (Arlington, Texas)

Air Force

Air Force

Air Force

No. 2 Ohio State at Northwestern

Ohio State

Ohio State

Ohio State

No. 17 North Carolina at Virginia

North Carolina

North Carolina

North Carolina

No. 19 Tulane at Tulsa

Tulane

Tulane

Tulane

Iowa at Purdue

Purdue

Purdue

Iowa

Minnesota at Nebraska

Minnesota

Minnesota

Minnesota

Kentucky at Missouri

Kentucky

Kentucky

Kentucky

Maryland at Wisconsin

Wisconsin

Wisconsin

Wisconsin

Georgia Tech at Virginia Tech

Virginia Tech

Virginia Tech

Virginia Tech

WKU at Charlotte

WKU

WKU

WKU

Marshall at Old Dominion

Marshall

Old Dominion

Marshall

USF at Temple

USF

USF

Temple

Baylor at Oklahoma

Oklahoma

Oklahoma

Oklahoma

Georgia State at Southern Miss

Southern Miss

Southern Miss

Southern Miss

Middle Tennessee at Louisiana Tech

Middle Tennessee

Middle Tennessee

Middle Tennessee

No. 8 Oregon at Colorado

Oregon

Oregon

Oregon

Michigan State at No. 14 Illinois

Illinois

Illinois

Illinois

No. 16 Penn State at Indiana

Penn State

Penn State

Penn State

No. 18 Oklahoma State at Kansas

Oklahoma State

Oklahoma State

Oklahoma State

No. 22 Syracuse at Pitt

Pitt

Syracuse

Pitt

No. 25 UCF at Memphis

UCF

UCF

UCF

West Virginia at Iowa State

Iowa State

Iowa State

Iowa State

Washington State at Stanford

Washington State

Washington State

Washington State

UTSA at UAB

UTSA

UTSA

UAB

New Mexico at Utah State

Utah State

Utah State

Utah State

No. 23 Liberty at Arkansas

Arkansas

Arkansas

Arkansas

Navy at Cincinnati

Cincinnati

Cincinnati

Cincinnati

South Alabama at Georgia Southern

South Alabama

South Alabama

South Alabama

FIU at North Texas

North Texas

North Texas

North Texas

Troy at Louisiana

Troy

Troy

Louisiana

Texas State at ULM

ULM

ULM

Texas State

BYU at Boise State

Boise State

Boise State

Boise State

Houston at SMU

Houston

Houston

SMU

UNLV at San Diego State

San Diego State

San Diego State

San Diego State

No. 4 Michigan at Rutgers

Michigan

Michigan

Michigan

Arizona at No. 12 Utah

Utah

Utah

Utah

Auburn at Mississippi State

Mississippi State

Mississippi State

Mississippi State

South Carolina at Vanderbilt

South Carolina

South Carolina

South Carolina

James Madison at Louisville

Louisville

James Madison

James Madison

California at No. 9 USC

USC

USC

USC

No. 10 UCLA at Arizona State

UCLA

UCLA

UCLA

Colorado State at San José State

San Jose State

San Jose State

San Jose State

Hawaii at Fresno State

Fresno State

Fresno State

Fresno State

Florida at Texas A&M

Texas A&M

Texas A&M

Texas A&M

Florida State at Miami

Florida State

Florida State

Florida State

Texas at No. 13 Kansas State

Texas

Kansas State

Texas

Texas Tech at No. 7 TCU

TCU

TCU

TCU

No. 20 Wake Forest at No. 21 NC State

Wake Forest

Wake Forest

Wake Forest

No. 5 Clemson at Notre Dame

Clemson

Clemson

Clemson

No. 6 Alabama at No. 15 LSU

Alabama

Alabama

Alabama

No. 2 Tennessee at No. 1 Georgia

Georgia

Georgia

Georgia

Ball State at Toledo (Tues.)

Toledo

Toledo

Toledo

Eastern Michigan at Akron (Tues.)

Eastern Michigan

Eastern Michigan

Eastern Michigan

Ohio at Miami (Ohio) (Tues.)

Miami (Ohio)

Ohio

Miami (Ohio)

Podcast: A Breakdown of the Auburn Job + Potential Candidates. Complete Week 10 Preview, Predictions and Picks Against the Spread.