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College Football Picks: Expert Predictions for Every Game in Week 12

College football's Week 12 slate for the 2022 season features 66 total games, and our NCAA experts are ready with their predictions and picks.

MACtion got things started with two games on Tuesday night, which saw Bowling Green become bowl eligible following a last-second touchdown to defeat Toledo (those picks were included in last week's table). The conference has three more games on tap on Wednesday, including a rivalry contest between Western Michigan and Central Michigan. There's just one college game (SMU-Tulane) scheduled for Thursday with USF-Tulsa and San Diego State-New Mexico both taking place on Friday night.

The early wave of games on Saturday features TCU at Baylor in a key Big 12 matchup as well as Illinois-Michigan, Wisconsin-Nebraska, Florida-Vanderbilt, and Boston College-Notre Dame. The mid-afternoon window includes Georgia-Kentucky, Miami-Clemson, Texas-Kansas, and the rivalry game between Iowa and Minnesota. The late-afternoon window also will feature the latest installment of the Big Game between Stanford and California. That evening, the marquee matchups include a crosstown rivalry showdown between USC and UCLA, as well as Tennessee-South Carolina, Ole Miss-Arkansas, and Bedlam between Oklahoma State and Oklahoma. The last set of games on Saturday features a rematch of last year's Pac-12 title game between Utah and Oregon, as well as Colorado at Washington, and a handful of Mountain West matchups.

Coastal Carolina was supposed to play Virginia in Charlottesville, but that game was canceled following the tragic on-campus shooting on Sunday night that took the lives of three UVA football players and injured another as well as a female student.

Each week, Athlon Sports’ editors will pick every game in the FBS ranks. Follow us on Twitter: (@AthlonSports)

College Football Picks: Expert Predictions for Every Game in Week 12

Steven LassanMark RossBen Weinrib

Miami (Ohio) at Northern Illinois (Wed.)

Miami (Ohio)

Miami (Ohio)

Northern Illinois

Eastern Michigan at Kent State (Wed.)

Kent State

Kent State

Eastern Michigan

Western Michigan at Central Michigan (Wed.)

Central Michigan

Central Michigan

Central Michigan

SMU at Tulane (Thurs.)

Tulane

Tulane

Tulane

San Diego State at New Mexico (Fri.)

San Diego State

San Diego State

San Diego State

USF at Tulsa (Fri.)

Tulsa

Tulsa

Tulsa

Navy at UCF

UCF

UCF

UCF

Austin Peay at Alabama

Alabama

Alabama

Alabama

Wisconsin at Nebraska

Wisconsin

Wisconsin

Wisconsin

Florida at Vanderbilt

Florida

Florida

Florida

Northwestern at Purdue

Purdue

Purdue

Purdue

Indiana at Michigan State

Michigan State

Michigan State

Michigan State

Duke at Pitt

Pitt

Pitt

Pitt

Virginia Tech at Liberty

Liberty

Liberty

Liberty

UConn at Army

Army

UConn

Army

Louisiana at Florida State

Florida State

Florida State

Florida State

ETSU at Mississippi State

Mississippi State

Mississippi State

Mississippi State

UMass at Texas A&M

Texas A&M

Texas A&M

Texas A&M

UTSA at Rice

UTSA

UTSA

UTSA

Kansas State at West Virginia

Kansas State

Kansas State

Kansas State

Washington State at Arizona

Washington State

Washington State

Washington State

Houston at East Carolina

East Carolina

East Carolina

East Carolina

Georgia State at James Madison

James Madison

James Madison

James Madison

North Alabama at Memphis

Memphis

Memphis

Memphis

Oregon State at Arizona State

Oregon State

Oregon State

Oregon State

Boston College at Notre Dame

Notre Dame

Notre Dame

Notre Dame

Old Dominion at Appalachian State

Appalachian State

Appalachian State

Appalachian State

Ohio State at Maryland

Ohio State

Ohio State

Ohio State

Miami at Clemson

Clemson

Clemson

Clemson

Penn State at Rutgers

Penn State

Penn State

Penn State

Texas at Kansas

Texas

Texas

Texas

NC State at Louisville

Louisville

Louisville

Louisville

South Alabama at Southern Miss

South Alabama

South Alabama

South Alabama

Akron at Buffalo

Buffalo

Buffalo

Buffalo

Florida Atlantic at Middle Tennessee

Florida Atlantic

Florida Atlantic

Florida Atlantic

Louisiana Tech at Charlotte

Charlotte

Louisiana Tech

Charlotte

ULM at Troy

Troy

Troy

Troy

Utah Tech at BYU

BYU

BYU

BYU

Cincinnati at Temple

Cincinnati

Cincinnati

Cincinnati

WKU at Auburn

Auburn

Auburn

WKU

FIU at UTEP

UTEP

UTEP

UTEP

Arkansas State at Texas State

Texas State

Texas State

Texas State

Georgia Tech at North Carolina

North Carolina

North Carolina

North Carolina

Marshall at Georgia Southern

Marshall

Marshall

Marshall

Tennessee at South Carolina

Tennessee

Tennessee

Tennessee

Texas Tech at Iowa State

Iowa State

Texas Tech

Iowa State

Boise State at Wyoming

Boise State

Boise State

Boise State

New Mexico State at Missouri

Missouri

Missouri

Missouri

Syracuse at Wake Forest

Wake Forest

Wake Forest

Wake Forest

UAB at LSU

LSU

LSU

LSU

Colorado at Washington

Washington

Washington

Washington

Colorado State at Air Force

Air Force

Air Force

Air Force

San Jose State at Utah State

San Jose State

San Jose State

San Jose State

Fresno State at Nevada

Fresno State

Fresno State

Fresno State

UNLV at Hawaii

UNLV

UNLV

UNLV

Illinois at Michigan

Michigan

Michigan

Michigan

TCU at Baylor

TCU

TCU

TCU

Georgia at Kentucky

Georgia

Georgia

Georgia

Iowa at Minnesota

Iowa

Minnesota

Minnesota

Stanford at California

California

California

California

Ole Miss at Arkansas

Arkansas

Arkansas

Ole Miss

Oklahoma State at Oklahoma

Oklahoma

Oklahoma

Oklahoma

USC at UCLA

USC

USC

USC

Utah at Oregon

Oregon

Utah

Oregon

Ball State at Miami (Ohio) (Tues.)

Miami (Ohio)

Miami (Ohio)

Miami (Ohio)

Bowling Green at Ohio (Tues.)

Ohio

Ohio

Ohio

Podcast: Week 12 Preview, Predictions and Picks Against the Spread + Reaction to CFB Playoff Top 25 Rankings

Note: The Coastal Carolina-Virginia game that was scheduled for Nov. 19 was canceled following the tragic on-campus shooting that occurred this past Sunday night in Charlottesville.