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College Football Picks: Expert Predictions for Every Game in Week 4

College football's Week 4 slate for the 2022 season features 66 games, and our NCAA experts are ready with their predictions and picks.

The Week 4 slate begins on Thursday night with three matchups, including West Virginia-Virginia Tech and Coastal Carolina-Georgia State. The action continues on Friday with three more contests, as Virginia-Syracuse and Boise State-UTEP top the list of intriguing matchups. The first wave of games on Saturday includes Clemson-Wake Forest, Maryland-Michigan, Baylor-Iowa State, SMU-TCU, Duke-Kansas and Missouri-Auburn. Florida-Tennessee, Notre Dame-North Carolina, Minnesota-Michigan State, Indiana-Cincinnati and Oregon-Washington State headline the afternoon slate. The first night window includes Arkansas-Texas A&M in Arlington, Wisconsin-Ohio State, Iowa-Rutgers and Kansas State-Oklahoma. The late-night action features USC-Oregon State, Wyoming-BYU and Utah-Arizona State.

Each week, Athlon Sports’ editors will pick every game in the FBS ranks. Follow us on Twitter: (@AthlonSports)

College Football Picks: Expert Predictions for Every Game in Week 4

Steven LassanMark RossBen Weinrib

West Virginia at Virginia Tech (Thurs.)

West Virginia

West Virginia

Virginia Tech

Coastal Carolina at Georgia State (Thurs.)

Coastal Carolina

Coastal Carolina

Coastal Carolina

Chattanooga at Illinois (Thurs.)

Illinois

Illinois

Illinois

Virginia at Syracuse (Fri.)

Syracuse

Syracuse

Syracuse

Nevada at Air Force (Fri.)

Air Force

Air Force

Air Force

Boise State at UTEP (Fri.)

Boise State

Boise State

Boise State

Saturday, September 24

Kent State at Georgia

Georgia

Georgia

Georgia

Maryland at Michigan

Michigan

Michigan

Michigan

Central Michigan at Penn State

Penn State

Penn State

Penn State

Rhode Island at Pitt

Pitt

Pitt

Pitt

Missouri at Auburn

Auburn

Auburn

Auburn

Bowling Green at Mississippi State

Mississippi State

Mississippi State

Mississippi State

TCU at SMU

SMU

SMU

SMU

Duke at Kansas

Kansas

Kansas

Kansas

USF at Louisville

Louisville

Louisville

Louisville

Buffalo at Eastern Michigan

Eastern Michigan

Eastern Michigan

Eastern Michigan

UCLA at Colorado

UCLA

UCLA

UCLA

UMass at Temple

Temple

Temple

Temple

Fordham at Ohio

Ohio

Ohio

Ohio

Minnesota at Michigan State

Michigan State

Minnesota

Minnesota

Middle Tennessee at Miami

Miami

Miami

Miami

James Madison at Appalachian State

Appalachian State

James Madison

Appalachian State

Toledo at San Diego State

Toledo

Toledo

Toledo

FIU at WKU

WKU

WKU

WKU

North Texas at Memphis

Memphis

Memphis

Memphis

Texas Southern at UTSA

UTSA

UTSA

UTSA

Indiana at Cincinnati

Cincinnati

Cincinnati

Cincinnati

Georgia Tech at UCF

UCF

UCF

UCF

Tulsa at Ole Miss

Ole Miss

Ole Miss

Ole Miss

Sacramento State at Colorado State

Colorado State

Colorado State

Colorado State

Arizona at California

California

Arizona

California

Akron at Liberty

Liberty

Liberty

Liberty

Navy at East Carolina

East Carolina

East Carolina

East Carolina

Ball State at Georgia Southern

Georgia Southern

Georgia Southern

Georgia Southern

Arkansas State at Old Dominion

Old Dominion

Old Dominion

Old Dominion

Rice at Houston

Houston

Houston

Houston

Northern Illinois at Kentucky

Kentucky

Kentucky

Kentucky

Iowa at Rutgers

Iowa

Iowa

Iowa

Southern Miss at Tulane

Tulane

Tulane

Tulane

UNLV at Utah State

Utah State

UNLV

Utah State

Houston Baptist at Texas State

Texas State

Texas State

Texas State

Marshall at Troy

Marshall

Marshall

Marshall

Louisiana Tech at South Alabama

South Alabama

South Alabama

South Alabama

Vanderbilt at Alabama

Alabama

Alabama

Alabama

UConn at NC State

NC State

NC State

NC State

New Mexico at LSU

LSU

LSU

LSU

Miami (Ohio) at Northwestern

Northwestern

Northwestern

Northwestern

Charlotte at South Carolina

South Carolina

South Carolina

South Carolina

Florida Atlantic at Purdue

Purdue

Purdue

Purdue

Kansas State at Oklahoma

Oklahoma

Oklahoma

Oklahoma

Hawaii at New Mexico State

Hawaii

Hawaii

Hawai'i

Boston College at Florida State

Florida State

Florida State

Florida State

Louisiana at ULM

Louisiana

Louisiana

Louisiana

Wyoming at BYU

BYU

BYU

BYU

Utah at Arizona State

Utah

Utah

Utah

Stanford at Washington

Washington

Washington

Washington

Western Michigan at San Jose State

San Jose State

San Jose State

San Jose State

Oregon at Washington State

Oregon

Oregon

Oregon

Notre Dame at North Carolina

North Carolina

North Carolina

Notre Dame

Texas at Texas Tech

Texas

Texas

Texas

Baylor at Iowa State

Iowa State

Baylor

Baylor

Wisconsin at Ohio State

Ohio State

Ohio State

Ohio State

USC at Oregon State

USC

USC

USC

Clemson at Wake Forest

Clemson

Clemson

Clemson

Florida at Tennessee

Tennessee

Tennessee

Tennessee

Arkansas vs. Texas A&M (Arlington, TX)

Arkansas

Arkansas

Texas A&M