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College Football Picks: Expert Predictions for Every Game in Week 6

College football's Week 6 slate for the 2022 season features 57 games, and our NCAA experts are ready with their predictions and picks.

The Week 6 slate begins on Wednesday night with SMU taking on UCF in Orlando. The action continues on Friday with four more contests, as Nebraska-Rutgers and UNLV-San Jose State top the list of intriguing matchups. The first wave of games on Saturday includes Tennessee-LSU, TCU-Kansas, Arkansas-Mississippi State, Texas-Oklahoma (in Dallas), and Purdue-Maryland. Auburn-Georgia, Texas Tech-Oklahoma State, Utah-UCLA, Virginia Tech-Pitt, Ohio State-Michigan State and North Carolina-Miami headline the afternoon slate. The first night window includes Clemson-Boston College, Washington State-USC, South Carolina-Kentucky, Iowa-Illinois, Texas A&M-Alabama, Florida State-NC State, and Notre Dame-BYU in Las Vegas. The late-night action features Oregon-Arizona, Fresno State-Boise State and Oregon State-Stanford. 

Each week, Athlon Sports’ editors will pick every game in the FBS ranks. Follow us on Twitter: (@AthlonSports)

College Football Picks: Expert Predictions for Every Game in Week 6

Steven LassanMark RossBen Weinrib

SMU at UCF (Wed.)

UCF

UCF

UCF

Nebraska at Rutgers (Fri.)

Nebraska

Nebraska

Nebraska

Houston at Memphis (Fri.)

Houston

Houston

Memphis

Colorado State at Nevada (Fri.)

Nevada

Nevada

Nevada

UNLV at San Jose State (Fri.)

San Jose State

San Jose State

San Jose State

Michigan at Indiana

Michigan

Michigan

Michigan

Arkansas at Mississippi State

Mississippi State

Arkansas

Mississippi State

Missouri at Florida

Florida

Florida

Florida

Purdue at Maryland

Purdue

Maryland

Maryland

Louisville at Virginia

Louisville

Louisville

Eastern Michigan at Western Michigan

Western Michigan

Western Michigan

Western Michigan

Buffalo at Bowling Green

Bowling Green

Bowling Green

Georgia Southern at Georgia State

Georgia State

Georgia State

Georgia State

Akron at Ohio

Ohio

Ohio

Ohio

USF at Cincinnati

Cincinnati

Cincinnati

Cincinnati

Virginia Tech at Pitt

Pitt

Pitt

Pitt

Wisconsin at Northwestern

Wisconsin

Wisconsin

Wisconsin

East Carolina at Tulane

Tulane

Tulane

Tulane

Tulsa at Navy

Tulsa

Tulsa

Tulsa

Middle Tennessee at UAB

UAB

UAB

UAB

Kent State at Miami (Ohio)

Kent State

Kent State

Miami (Ohio)

Ball State at Central Michigan

Central Michigan

Central Michigan

Central Michigan

Toledo at Northern Illinois

Toledo

Toledo

Toledo

Liberty at UMass

Liberty

Liberty

Liberty

Ohio State at Michigan State

Ohio State

Ohio State

Ohio State

Ole Miss at Vanderbilt

Ole Miss

Ole Miss

Ole Miss

Washington at Arizona State

Washington

Washington

Washington

North Carolina at Miami

Miami

Miami

Miami

Duke at Georgia Tech

Duke

Georgia Tech

Duke

WKU at UTSA

UTSA

UTSA

UTSA

Air Force at Utah State

Air Force

Air Force

Air Force

Wyoming at New Mexico

Wyoming

Wyoming

Wyoming

James Madison at Arkansas State

James Madison

James Madison

James Madison

Appalachian State at Texas State

Appalachian State

Appalachian State

Appalachian State

Southern Miss at Troy

Troy

Troy

Troy

UTEP at Louisiana Tech

UTEP

UTEP

UTEP

UConn at FIU

UConn

UConn

UConn

Clemson at Boston College

Clemson

Clemson

Clemson

South Carolina at Kentucky

Kentucky

Kentucky

Kentucky

Army at Wake Forest

Wake Forest

Wake Forest

Wake Forest

Kansas State at Iowa State

Kansas State

Kansas State

Kansas State

Iowa at Illinois

Illinois

Illinois

Iowa

Coastal Carolina at UL Monroe

Coastal Carolina

Coastal Carolina

Coastal Carolina

Oregon at Arizona

Oregon

Oregon

Oregon

Fresno State at Boise State

Boise State

Boise State

Fresno State

Hawaii at San Diego State

San Diego State

San Diego State

San Diego State

Oregon State at Stanford

Oregon State

Oregon State

Oregon State

Florida State at NC State

NC State

NC State

NC State

Texas Tech at Oklahoma State

Oklahoma State

Oklahoma State

Oklahoma State

Washington State at USC

USC

USC

USC

BYU vs. Notre Dame (Las Vegas)

Notre Dame

Notre Dame

Notre Dame

TCU at Kansas

Kansas

Kansas

TCU

Utah at UCLA

Utah

Utah

UCLA

Auburn at Georgia

Georgia

Georgia

Georgia

Tennessee at LSU

Tennessee

Tennessee

Tennessee

Texas A&M at Alabama

Alabama

Alabama

Alabama

Texas vs. Oklahoma (Dallas)

Texas

Texas

Texas

Podcast: Week 6 Preview, Predictions, the Latest in Coaching Changes, and Picks Against the Spread