Skip to main content

College Football Picks and Predictions Against the Spread for Top 25 Games in Week 6

Week 6 of the 2022 college football season features several high-profile and interesting matchups to bet against the spread, including Texas A&M-Alabama, Florida State-NC State, Utah-UCLA, and Clemson-Boston College. Also, the Week 6 slate includes South Carolina-Kentucky, Washington State-USC, Notre Dame-BYU (Las Vegas), Oregon-Arizona, TCU-Kansas, and Auburn-Georgia. And if you are looking to wager or bet against the spread on any of these games or Top 25 contests, our NCAA experts are ready with their predictions and picks.

Related: College Football Predictions for Every Game in Week 6

Athlon Sports picks the 20* matchups involving Top 25 teams against the spread for Week 6:

SpreadSteven LassanMark RossBen Weinrib

USF at No. 24 Cincinnati

CIN -28

Cincinnati

Cincinnati

Cincinnati

Arkansas at No. 23 Mississippi State

MSST -8

Arkansas

Arkansas

Mississippi State

No. 21 Washington at Arizona State

WASH -14

Arizona State

Washington

Arizona State

No. 20 Kansas State at Iowa State

KSU -2

Kansas State

Kansas State

Iowa State

No. 17 TCU at No. 19 Kansas

TCU -7

Kansas

Kansas

TCU

No. 16 BYU vs. Notre Dame (Las Vegas)

ND -3.5

BYU

Notre Dame

Notre Dame

Army at No. 15 Wake Forest

WF -17

Army

Wake Forest

Army

Florida State at No. 14 NC State

NC -3.5

Florida State

NC State

NC State

South Carolina at No. 13 Kentucky

UK -10.5

South Carolina

Kentucky

Kentucky

No. 12 Oregon at Arizona

ORE -13

Oregon

Oregon

Oregon

No. 11 Utah at No. 18 UCLA

UTAH -4.5

UCLA

Utah

UCLA

No. 9 Ole Miss at Vanderbilt

MISS -18

Vanderbilt

Ole Miss

Ole Miss

No. 8 Tennessee at No. 25 LSU

TENN -3

Tennessee

Tennessee

LSU

Texas Tech at No. 7 Oklahoma State

OKST -9.5

Oklahoma State

Oklahoma State

Oklahoma State

Washington State at No. 6 USC

USC -13

Washington State

Washington State

Washington State

No. 5 Clemson at Boston College

CLEM -20.5

Clemson

Boston College

Boston College

No. 4 Michigan at Indiana

MICH -22

Michigan

Michigan

Michigan

No. 3 Ohio State at Michigan State

OSU -26.5

Ohio State

Michigan State

Michigan State

Auburn at No. 2 Georgia

UGA -30

Georgia

Auburn

Auburn

Texas A&M at No. 1 Alabama

ALA -24

Alabama

Texas A&M

Texas A&M

Podcast: Week 6 Preview, Predictions, The Latest in Coaching Changes, and Picks Against the Spread

*Top 25 teams on bye in Week 6: No. 10 Penn State, No. 22 Syracuse.