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College Football Upset Watch for Week 6: More Top-10 Teams Set to Fall?

Clemson and USC both have tricky tests to navigate in prime time on Saturday.

Welcome to Week 6 of the college football "Upset Watch" here at Athlon Sports!

If your team is on this list, you have every reason to be nervous. We've had at least one team from each of the first five weeks of "upset watch" go down to underdogs. Last week, it was Minnesota losing at home to Purdue. Who will it be this week?

Related: College Football Predictions for Every Game in Week 6

Let's take a look at the five teams on "upset watch" for Week 6.

Florida (vs. Missouri)

12 p.m. ET on ESPNU, live stream on fuboTV (Start your free trial)

Missouri gave Georgia a serious scare last week, leading the Bulldogs for most of that game. Now the Tigers travel to Gainesville for an early kickoff, confident that they can hang with any team in the country. Florida had a bit of a rebound game last week against FCS foe Eastern Washington. Now the Gators need to dial up the intensity again for the first time since losing to Tennessee two weeks ago. If the home team doesn't bring its "A" game into The Swamp, Billy Napier and company will be 0-3 in SEC play.

No. 13 Kentucky (vs. South Carolina)

7:30 p.m. ET on SEC Network, live stream on fuboTV (Start your free trial)

The Wildcats are coming off an emotional and hard-fought loss to Ole Miss that knocked them out of the top 10. The loss also makes it very difficult for Kentucky to climb back into the College Football Playoff conversation. Now UK needs to test its resilience and reset. South Carolina comes in as double-digit underdogs looking to completely derail Kentucky's season. The Gamecocks are in search of their first SEC win. They've already seen the toughest team they'll face all season (Georgia), and they've got the talent to a man to go blow for blow with the Wildcats. Especially if quarterback Will Levis sits this one out due to injury, which is being reported as a distinct possibility.

No. 12 Oregon (at Arizona)

9 p.m. ET on Pac-12 Networks, live stream on fuboTV (Start your free trial)

We still don't know who Oregon is. After getting blown out against Georgia to kick off the year, the Ducks still haven't looked overly dominant against FBS competition. Now they'll travel to Tucson to take on a Wildcats squad that has played a solid schedule so far, even logging a win over FCS juggernaut North Dakota State — which is no small feat. You never know what could happen when it comes to #Pac12AfterDark. The Ducks — favored by nearly two touchdowns  better be ready for a fight.

No. 6 USC (vs. Washington State)

7:30 p.m. ET on FOX, live stream on fuboTV (Start your free trial)

Washington State is a three-point loss to Oregon (in a game that the Cougars led by 12 with less than seven minutes left in the fourth quarter) away from being unbeaten and sporting a pretty solid resume. Despite that, the Cougars will be nearly two-touchdown underdogs when they travel to L.A. to face the Trojans on Saturday. Wazzu has proved it can compete in shootouts or low-scoring, grind-it-out games. The question is, which one of those is USC willing to endure in order to keep its (and the Pac-12's) College Football Playoff hopes alive? And will the Trojans be looking ahead to the matchup at Utah next week? This could be one of the low-key most entertaining games of the weekend.

No. 5 Clemson (at Boston College)

7:30 p.m. ET on ABC, live stream on fuboTV (Start your free trial)

Clemson will be nearly a three-touchdown favorite traveling to Chestnut Hill to take on Boston College. The Eagles are feeling pretty good after winning a barn-burner against Louisville last week  a game that could have changed the trajectory of their season. As good as the Tigers are, we've seen better Dabo Swinney teams lose to similar competition and talent as to what Boston College will field on Saturday. Keep one eye on the score of this one early. If it's close in the first half, it'll probably be close the whole way.

Podcast: Week 6 Preview, Predictions, the Latest in Coaching Changes, and Picks Against the Spread

— Written by J.P. Scott, who is part of the Athlon Contributor Network. His work has appeared on SI.com, FoxSports.com, Yahoo! SBNation and Bleacher Report. He is a three-time FWAA writing contest award winner. Follow him on Twitter @TheJPScott.