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College Football Week 5 Upset Predictions

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The final weekend of college football action in September once again features several non-conference matchups, but more competitive games are coming soon.

Conference play for nearly all 10 leagues is starting to pop up more on the schedule each Saturday, with the SEC, Big Ten and Pac-12 featuring a handful of key games in Week 5.

Wisconsin-Ohio State, Ole Miss-Alabama, LSU-Georgia, Notre Dame-Oklahoma and Arizona State-USC are just a few of the key games on the schedule this Saturday. This weekend’s slate is a huge improvement over Week 4’s schedule, which was very light in terms of quality games.

The favorites can't win every game each week, so it's no surprise one of the most popular discussion points every Saturday is upset picks. Each week on AthlonSports.com, the editors will give an upset pick for the upcoming week of action.

Week 5 Previews and Predictions: ACCBig 12 | Big Ten | Pac-12SEC

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College Football Week 5 Upset Predictions

Steven Lassan (@AthlonSteven): Buffalo (+1) over Connecticut
I realize this isn’t much of an upset, but I’m also not seeing many games the underdog will win on Saturday. Connecticut played Michigan tough last week, but the Huskies gained only 206 yards, and quarterback Chandler Whitmer was sacked four times. Buffalo’s defense features one of the nation’s most underrated players in linebacker Khalil Mack, and six other starters from a unit that held opponents to 363.7 yards per game last year. The Bulls’ rank last in the MAC in total defense this season, but the competition played so far – Ohio State and Baylor – have a lot to do with that number. Connecticut coach Paul Pasqualoni desperately needs a win to cool some of the hot seat talk in Storrs. However, Buffalo’s defense, and running back Branden Oliver prevent the Huskies from getting a much-needed victory.

David Fox (@DavidFox615): Colorado (-11) over Oregon State
The Buffaloes are a much improved team. I don’t expect them to go to a bowl, but this team went from absolutely dreadful to 2-0. In this game, Oregon State’s defense will give the Buffs a chance. Oregon State needed late surges to beat San Diego State and Utah. I wonder how much the Beavers will be able to hold up. Colorado can move the ball thanks to Connor Wood completing passes to the nation’s most underrated receiver Paul Richardson (though the Beavers’ Brandin Cooks is in the same class). With the way Oregon State’s D has been playing, it’s tough to envision the Beavers as an 11-point favorite over anyone.

Mark Ross: Western Kentucky (+3) over Navy
Navy is leading the nation in rushing at nearly 400 yards per game and already has a win over a Big Ten team (Indiana) on its resume. However, Western Kentucky can match up with the Midshipmen when it comes to running the ball, as the Hilltoppers are gaining nearly 230 yards on the ground per contest themselves. New WKU coach Bobby Petrino has this offense clicking, and I think the combination of all-purpose threat Antonio Andrews (222.2 total yards per game) and the passing ability of Brandon Doughty will be too much for the Mids to overcome in Smith Stadium in Bowling Green, Ky. Don't be surprised if this game features close to 600 yards rushing and more than 80 points combined.

Braden Gall (@BradenGall): USC (+7) at Arizona State
This is a huge game for both teams as the loser will be sitting at 0-2 in the Pac-12 after just one month of play. USC's defense is the real deal, and Arizona State has struggled in a big way along the line of scrimmage against Stanford. Historically, the Trojans have owned the Sun Devils, winning 12 of the last 13 meetings. Lane Kiffin will take the air out of the football by running Tre Madden and playing great defense. Don't be surprised if the desperate Men of Troy return to Los Angeles with a big leg up in the South Division.

Stephen Schindler (@SteveSchindler): Virginia (+5) over Pittsburgh
Mike London knows the key to taking down the Panthers is limiting the big play. Last week, 17 of Pittsburgh's plays accounted for 423 yards of their 598 total yards. The Panthers do an excellent job of running the ball to open up their play action passing game, in order to take advantage of their two top-notch receivers Devin Street and Tyler Boyd. Despite this, I like Virginia’s new aggressive approach under defensive coordinator Jon Tenuta. While they struggled against Oregon (who doesn’t?), the Cavaliers defense looked dominant in wins over BYU and VMI. In fact, Virginia registered six sacks, 12.5 tackles for a loss and five turnovers in the two games. They have held all three of their opponents under their season scoring average. I like what the Cavaliers rushing attacks will be able to do against a Panthers defense that allows an average of 443 yards and 41 points per game, ranking 120th in the FBS. The Panthers have allowed their last two opponents, New Mexico and Duke, to each rush for 213 yards. Look for a big game from Cavaliers RB Kevin Parks, who rushed for a career-high 135 yards last week. I like the Cavaliers defense and running game over the high-flying Pittsburgh offense in this one.

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