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NFL DFS: Best DraftKings and FanDuel Predictions and Picks for Week 6

Flex Rankings Week 9: Sterling Shepard

After missing the past two games because of a hamstring injury, Sterling Shepard is expected to return on Sunday against the Rams and could be a value DFS pick

I arrive with my Week 6 daily fantasy football (DFS) picks coming in pretty hot. Hunter Henry, Larry Fournette, and the Tampa Bay defense/special teams were just a few of the picks I slam-dunked last week.

Can I do it again this week? Here's hoping, but recall this is the first week involving byes, which always makes things a little more interesting as there just naturally is going to be more overlap due to smaller player fields.

Week 6 Positional Rankings: QB I RB I WR I TE I DST I K I Flex

And keep that in mind as I go through each position and list one "safe" pick and one "high-risk/high-reward" pick. For those of you familiar with DFS, the first is essentially a cash-game play and the second is a GPP play. I also will make sure that said player is priced proportionately about the same across DraftKings, FanDuel, and the other major sites. For those of you unfamiliar with DFS, do yourself a favor and look up cash games vs. GPPs. Or hit me up on Twitter (@MarkStrausberg) and I will explain it to you personally.

Safe Quarterback Week 6 Pick

Kyler Murray, Arizona Cardinals at Cleveland Browns (DK $7900, FD $8400)

The quarterback of the lone undefeated team who is completing the highest percentage of passes in the league going against a team that is giving up the ninth-most fantasy points to QBs? Yeah, that feels like a pretty safe pick.

High Risk/Reward Quarterback Week 6 Pick

Lamar Jackson, Baltimore Ravens vs. Los Angeles Chargers (DK $7200, FD $8200)

Most folks will either go the cheaper route with someone like Taylor Heinicke or spend all the way up and grab Patrick Mahomes. Even if they go with another high-priced alternative, my guess is they will go with the cheaper alternative in Justin Herbert. That makes Jackson a high-leverage possibility and he's been crushing it lately, coming off of a four-touchdown, 472-yard passing day. It inspired Jim Irsay, yes he whose father couldn't wait to get out of Baltimore, to post this tweet:

When you're being put above Gayle Sayers, that's pretty lofty company!

Related: Start 'Em, Sit 'Em Week 6 QB/TE/DST Fantasy Advice

Safe Running Back Week 6 Pick

Austin Ekeler, Los Angeles Chargers at Baltimore Ravens (DK $7900, FD $8400)

Of course on the other side of the ball in addition to Justin Herbert is the running back tied for the league lead in TDs. And while Derrick Henry and Ekeler are both tied (seven each), Henry is not available on the main slate. Add in the fact that Baltimore is giving up the sixth-most fantasy points to RBs this season and Ekeler will be heavily owned for good reason. If you're playing cash games, you almost can't afford NOT to play him.

High Risk/Reward Running Back Week 6 Pick

Javonte Williams, Denver Broncos vs. Las Vegas Raiders  (DK $5000, FD $5600)

Do you know who has been even worse against RBs than Baltimore? Yup, Miami. I like Jacksonville's James Robinson to give the Brits a jolly good show. There's been very little to get excited about with the Jags, but their running back is still getting it done. But depending on the site/slate you may be playing, Robinson might not be available.

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In that case, go with Williams. He's no longer a bargain and almost needs to be the bell cow to justify his price. I expect he will go low owned and if you need reasons to grab him, see my RB start/sit this week.

Related: Start 'Em, Sit 'Em Week 6 RB/WR Fantasy Advice

Safe Wide Receiver Week 6 Pick

Davante Adams, Green Bay Packers at Chicago Bears (DK $9000, FD $8500)

There are definitely some higher upside plays than Adams this week. But I believe it was Confucious who said, "He who has most catches likely get more."

High Risk/Reward Receiver Week 6 Pick

Sterling Shepard, New York Giants vs. Los Angeles Rams (DK $5000, FD $6200)

This is a very risky pick. First off, we still don't know who is quarterbacking on Sunday, although Daniel Jones has cleared concussion protocol and is expected to play. Also, Shepard is coming back from an injury and didn't even get a full week of practice in this week. Plus, the Rams have a pretty good secondary, right?

Yes, they do. However, with teams forced to play catch-up with the Rams, they are seeing a large volume of passes. And therefore, they are actually giving up the 10th-most passing yards. And with Shepard coming off the injury, he's under the radar. But let's not forget that before his injury, Shepard saw a combined 19 targets the first two weeks and averaged over 100 receiving yards a week. Shepard could totally disappoint, but this is exactly the kind of sneaky play that winning GPP lineups often include.

Safe Tight End Week 6 Pick

Travis Kelce, Kansas City Chiefs at Washington Football Team (DK $8500, FD $7000)

This is not sneaky at all and you know the reasons why to start Kelce.

Related: Fantasy Football 5 Up, 5 Down for Week 6

High Risk/High Reward Tight End Week 6 Pick

Donald Parham Jr., Los Angeles Chargers at Baltimore Ravens (DK $2900, FD $4900)

I think those considering using a TE in their second flex spot might put Jared Cook here. Not me! Read my start/sit under TEs for Week 6 for more detail.

Safe Defense/Special Teams (DST) Week 6 Pick

Los Angeles Rams at New York Giants (DK, $4700 FD $5000)

Sometimes it is just that easy.

High Risk/Reward Defense/Special Teams (DST) Week 6 Pick

Cincinnati Bengals at Detroit Lions (DK $3400, FD $4500)

Bengals are tied for seventh in sacks, 11th in INTs, and eighth in points allowed. They are taking on the Lions, who are tied for the eighth-fewest TDs. I love the value here.

— Written by Mark Strausberg, a member of the Athlon Network Contributor, who despite his youthful exuberance and good looks has been playing fantasy sports before Wildcats or Hoosiers even made it to VHS. Got a fantasy sports question or thought? Hit him up on Twitter @MarkStrausberg.