In Week 4, the number of players on the injury report who have fantasy impact is long enough to be broken into two parts. Below will cover the running backs and tight ends. Don't forget to check out the wide receivers too.
Unfortunately for fantasy owners, many of the players that are questionable are playing in the later games which will make lineup decisions tough. Players already ruled out include Andrew Luck, Sam Bradford, Darren Sproles (out for the season), Matt Forte, Marlon Mack, Dwayne Washington, Tyler Eifert, and Cairo Santos. In addition Rex Burkhead and C.J. Prosise are doubtful, so don't count on them either. Be sure to monitor the inactive reports before game time, and always have a backup plan.
Note: All times are ET and games are on Sunday, Oct. 1 unless otherwise noted.
Jay Ajayi (knee), RB, Miami Dolphins vs. New Orleans Saints, 9:30 a.m. (London)
All signs point to Ajayi playing today. It is a good matchup against the Saints, but so was last week against the Jets. He looked good in Week 2, but whether it was the game flow or the knee injury that limited him in Week 3 is unknown. He should play and is still a RB1, however, fantasy owners should just be a bit wary because of last week's performance. If there's a last-minute setback or change at least owners should have plenty of time to regroup since the London game kicks off at 9:30 a.m. ET.
Carlos Hyde (hip), RB, San Francisco 49ers at Arizona Cardinals, 4:05 p.m.
Hyde has earned a questionable tag and he may end up being a game-time decision, which is going to be tough for fantasy owners because of the later game time. He's still dealing with a hip injury, and odds are that he will play, but his role may be reduced. In Week 3, with this same injury, Hyde ran for 84 yards and two touchdowns. It's hard to bench someone that could produce that with this injury. If he's active, play Hyde and hope for the best. However, because he may be a game-time decision, have a backup plan just in case.
Melvin Gordon (knee), RB, Los Angeles Chargers vs. Philadelphia Eagles, 4:05 p.m.
Despite the questionable tag and some limited practices this week, Gordon is on track to play today. He had a bruised knee, and it appears this was aggravated last week. However, it isn't an injury that will keep him out of Week 4. He's scored a touchdown in each of three games this season. Philadelphia allowed Kareem Hunt to score two touchdowns and Chris Thompson to catch a TD pass, so the odds are that Gordon finds the end zone again. He's a RB1.
Rob Kelley (ribs), RB, Washington Redskins at Kansas City Chiefs, 8:30 p.m. (Mon.)
Even though he was able to practice on Saturday, Kelley is only a RB3 if active on Monday night. Fantasy owners should find other options. He's clearly banged up and limited, and after missing Week 3, he may not receive a full complement of snaps in Week 4. Chris Thompson has stepped up in Kelley's absence, scoring four touchdowns in the last three games. There is no reason to rush Kelley back, even if the Redskins insist that he's still their lead back.
Orleans Darkwa (back), RB, New York Giants at Tampa Bay Buccaneers, 4:05 p.m.
After suffering a back injury in Week 3, Darkwa should not be in fantasy lineups for Week 4. Heading into Week 3, it seemed that Darkwa may be given a shot to see what he can do, as Paul Perkins was struggling. However, after missing practices this week, it does not seem that Darkwa is going to be the lead back in Week 4, even if active. He should remain on benches everywhere, and those with deep benches may want to stash him in case he does earn a bigger role at some point.
Jordan Reed (ribs/shoulder), TE, Washington Redskins at Kansas City Chiefs, 8:30 p.m. (Mon.)
Reed sat out Week 3 with his numerous injuries, but he was able to practice this week. All signs point to him being active in Week 4, but the injuries have taken a toll on his performance so far. He had five and six receptions, respectively in the first two games, for 36 and 48 yards. He hasn't found the end zone. Fantasy owners of Reed should try to pick up Vernon Davis as well. If fantasy owners are counting on Reed for Week 4, having a backup is key. He's a TE2 if active because he may not make it through the game.
Ben Watson (calf), TE, Baltimore Ravens vs. Pittsburgh Steelers, 1 p.m.
After eight catches for 91 yards in Week 2, fantasy owners needing a tight end grabbed Watson off the waiver wire. His Week 3 was unimpressive, but he did find the end zone, saving his fantasy day. For Week 4, Watson is not a recommended fantasy option. He missed practice this week with a calf injury, but he did return to practice on Friday. He should play, but is a TE2.
— Written by Sarah Lewis, who is part of the Athlon Contributor network and lives, eats, and breathes fantasy football. She also writes for SoCalledFantasyExperts.com among other sites. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.