Even with two teams (New York Jets, San Francisco) on a bye, fantasy owners have plenty of injuries to key players to deal with in Week 4. Saquon Barkley suffered a high ankle sprain in Week 3 and is out for at least the next month. Jordan Reed is still recovering from a concussion, has already been ruled out, and may have to give up football.
In what could have been a great week against Miami, Justin Jackson is out, leaving Austin Ekeler to carry the load. At this point, it’s not clear if Melvin Gordon will be active or not. The coaching staff originally called him doubtful, but then said he may have a limited role. It doesn't sound like Gordon should be started in fantasy lineups for this week, but owners should have him for Week 5.
Here are the other key running back and tight end injuries. Keep an eye on the wide receivers (plus one quarterback) as well. And, as always, be sure to check the inactive report before the games on Sunday.
Teams on bye: New York Jets, San Francisco
Note: All times are ET and games are on Sunday, Sept. 29 unless otherwise noted.
Devin Singletary (hamstring), RB, Buffalo Bills vs. New England Patriots, 1 p.m.
Singletary left Week 2 with a hamstring injury and missed last week's game. However, he returned to practice on Thursday this past week, putting him on the radar to play on Sunday. If Singletary does play, it still will likely be Frank Gore getting most of the carries. The Bills likely don't want to rush Singletary back, and hamstring injuries can easily be re-aggravated. It's a tough matchup and the limited workload should be enough for fantasy owners to keep Singletary on the bench.
Rex Burkhead (foot), RB, New England Patriots at Buffalo Bills, 1 p.m.
Burkhead did put in limited practices this week, so fantasy owners shouldn't be concerned with the foot injury. The Patriots' backfield, however, does get a bit crowded with James White returning (he missed Week 3 for the birth of his child). Burkhead had 11 carries in Week 3, and he did get a touchdown. How the Patriots will use their backs is anyone’s guess, but don't let the foot injury be the reason you're benching Burkhead.
Rashaad Penny (hamstring), RB, Seattle Seahawks at Arizona Cardinals, 4:05 p.m.
Penny missed Week 3 with a hamstring injury, and the Seahawks have managed with Chris Carson and C.J. Prosise. Penny did get in limited practices this week, putting him on track to play Sunday afternoon. This backfield is just as messy as New England's, where Carson keeps fumbling the ball, but he is clearly who the Seahawks want to be their lead back. Penny will likely warm up on Sunday, but even if he's active, he figures to be limited. Fantasy owners should keep Penny on the bench for another week.
Mark Andrews (foot), TE, Baltimore Ravens vs. Cleveland Browns, 1 p.m.
After back-to-back weeks with eight receptions and a touchdown, Andrews came back down to earth in Week 3. He only had three receptions for 15 yards. Don't blame that on the foot injury, though, as he's been battling that all season. Andrews will likely be on the injury report for weeks, but will still suit up on Sundays. He's a TE1.
Trey Burton (groin), TE, Chicago Bears vs. Minnesota Vikings, 4:25 p.m.
Burton played through the groin injury the past two weeks. His reception total doubled from Week 2 to 3 (from two to four), but he still only had 20 receiving yards. He hasn't lived up to the TE2-bordering-on-TE1 hype from the preseason, but he's also been dealing with the groin injury. Burton will be active in Week 4, but he faces a tough matchup against the Vikings.
Vance McDonald (shoulder), TE, Pittsburgh Steelers vs. Cincinnati Bengals, 8:15 p.m. (Mon.)
It's actually surprising the McDonald drew the questionable tag instead of doubtful. He's been seen with his arm in a sling and the Steelers traded for Nick Vannett this week. While it is possible the team was just going for tight end depth (blocking tight end Xavier Grimble was put on injured reserve), it doesn't necessarily bode well for McDonald. He may try to play through the shoulder injury, but between Mason Rudolph, the injury, and the Monday night game, fantasy owners should have a backup plan in place.
— Written by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.