While many fantasy owners lost tight ends or wide receivers following Week 1, some running backs are going to make life tricky for them as well. The running backs aren’t as straightforward, so fantasy owners are likely going to have to check the inactive report before game time. Also remember, with running backs, if the injury is a hamstring or other soft tissue, the odds of re-injuring it are high. Devonta Freeman and Darren Sproles have already been ruled out. The players listed below are questionable. Be sure to also check out the QB/TE and WR injuries.
Note: All games are Sunday, Sept. 16 and times are ET.
Leonard Fournette (hamstring), RB, Jacksonville Jaguars vs. New England Patriots, 4:25 p.m.
Fournette left last week's game with a hamstring injury, leaving fantasy owners with nine carries for 41 yards and three receptions for 14 yards. He didn’t practice all week, and the Jaguars promoted another running back from their practice squad. All of these signs point to him being out. If, by chance, he is active, it’s not worth the risk to start him. Look for T.J. Yeldon to get the carries against the Patriots.
Rex Burkhead (concussion), RB, New England Patriots at Jacksonville Jaguars, 4:25 p.m.
Burkhead is going to be a player that fantasy owners should look to make sure is active before game time. He did travel with the team to Jacksonville, which is a good sign, but he is still in the concussion protocol. Since this is a late afternoon game, fantasy owners should be sure they have someone else to add in if needed. In Week 1, he had 18 carries for 64 yards and one reception for five yards. If Sony Michel makes his debut (see below), it will be Burkhead’s workload that he will cut into.
Sony Michel (knee), RB, New England Patriots at Jacksonville Jaguars, 4:25 p.m.
Michel missed Week 1 as he still is recovering from a knee scope he had at the beginning of August. He missed most of the preseason and is still waiting to make his NFL debut. While it does seem that Michel is ready to go, he will be hard to trust for fantasy purposes this week. Between James White and Rex Burkhead figuring into the mix as well as the knee injury, Michel may just use this game to ease into NFL action.
Marlon Mack (hamstring), RB, Indianapolis Colts at Washington Redskins, 1 p.m.
Mack missed Week 1 with a hamstring injury that he sustained in the first week of the preseason. While it is possible the Colts held him out to make sure the injury has healed, fantasy owners should be concerned with him pulling it again. It’s not a reason to sit him, but be aware. Also, Mack joins Nyheim Hines and Jordan Wilkins, who held down the running game in Week 1. This has the makings of a running back by committee, which brings down all of their values.
LeGarrette Blount (shoulder), RB, Detroit Lions at San Francisco 49ers, 4:05 p.m.
Blount suffered the shoulder injury in Week 1, and his numbers suffered as a result. He had four rushes for minus-three yards. His value is in the hope that he scores a touchdown, and that’s never a guarantee. There are too many men in the Lions' backfield and Blount is likely to be the odd man out. He will likely be active for Week 2, but should be kept on fantasy benches.
— Written by Sarah Lewis, who is part of the Athlon Contributor network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.