For fantasy owners, plenty of injuries have already impacted their teams. With the onslaught of injuries primarily to quarterbacks and tight ends, fantasy owners have been scrambling to the waiver wire to find replacements.
The list of players who bear the Questionable designation heading into Week 3 is lengthy, especially at the tight end position. Additionally, a bunch of key players have already been ruled out. That group includes: Drew Brees, Cam Newton, Damien Williams, Tevin Coleman, Devin Singletary, DeSean Jackson, Michael Gallup, Cody Latimer, Tre'Quan Smith, Hunter Henry, Jordan Reed, Tyler Higbee, and David Njoku, who just went on injured reserve this week. Others on IR include Derrius Guice and Ben Roethlisberger, who's done for the season, and the same could be said about Antonio Brown, who's not hurt but he is looking for another team and dealing with some serious off-field issues.
With so many injuries, be sure none of these names are still in your lineup and for anyone who is Questionable, be sure to check the inactive report before game time to make sure they are playing.
Note: All times are ET and all games are on Sunday, Sept. 22.
Marlon Mack (calf), RB, Indianapolis Colts vs. Atlanta Falcons, 1 p.m.
Mack missed practice on Wednesday and Thursday but he did return on Friday. Typically a Friday practice means that the player will suit up on Sunday. Fantasy owners should plan on having Mack in their lineup, but he may be in for less work than normal. After a huge Week 1 (174 rushing yards, TD), he came back to earth in Week 2 with 51 yards. He added two receptions for 12 yards, but overall, Mack should be treated as a low RB2 for Week 3.
Alshon Jeffery (calf), WR, Philadelphia Eagles vs. Detroit Lions, 1 p.m.
Jeffery missed practice all week, although he does not need to practice to play. All week there has been doubt if Jeffery would be able to suit up on Sunday. The latest reports are saying that he should play, but this may be a case where he is either a decoy or is on a very limited snap count. While Jeffery's fantasy owners may want to play him as usual, if possible, keep him on the bench for Week 3 if he's even active.
T.Y. Hilton (quad), WR, Indianapolis Colts vs. Atlanta Falcons, 1 p.m.
It certainly seems that Hilton will be ready to go in Week 3 after putting in limited practices all week. He has a quad injury, but it shouldn’t limit him in any way. He has three touchdowns through two weeks, although he hasn’t had any high-yardage weeks. He should still be started as a WR2. The Falcons defense can be beat through the air — they allowed more than 100 yards and a touchdown to Nelson Agholor last week even though the Eagles were without Alshon Jeffery and DeSean Jackson for most of that game.
LeSean McCoy (ankle), RB, Kansas City Chiefs vs. Baltimore Ravens, 1 p.m.
With Damien Williams (knee) already ruled out, McCoy should see more carries. However, he's been limited with an ankle injury, and the Chiefs will likely want to continue monitoring his touches. McCoy should play, but he's still an RB2 in what looks to be a high-scoring game. Darwin Thompson is an interesting DFS play as he might see additional work in Week 3.
Rashaad Penny (hamstring), RB, Seattle Seahawks vs. New Orleans Saints, 4:25 p.m.
Penny apparently injured his hamstring in practice on Friday. This is worrisome for fantasy owners as he doesn't have a lot of turnaround time before Sunday. While Penny did have a solid game in Week 2 (62 yards on the ground and touchdown), his Week 1 usage was not significant. If Penny is out, it bodes well for Chris Carson. However, if fantasy owners were looking for a reason to sit Penny, this is it.
— Written by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.