What makes it even harder is that many of these players are in the Monday night game. Fantasy owners are going to have to make some decisions before Monday night as some players may not be active.
These running backs have already been ruled out: Leonard Fournette, Dalvin Cook, Marshawn Lynch, Bilal Powell, Royce Freeman, Giovani Bernard, Theo Riddick and Darren Sproles. Sony Michel is doubtful and even though he returned to practice on Saturday, fantasy owners should not plan on starting him this week.
Don't forget to check out the rundown on the quarterback/wide receiver/kicker injuries and be sure to consult the inactive report before game time to avoid any unwanted surprises.
Teams on bye: Atlanta, Dallas, Los Angeles Chargers, Tennessee
Note: All times are ET and all games are on Sunday, Oct. 28 unless listed otherwise.
Rob Gronkowski (back), TE, New England Patriots vs. Buffalo Bills, 8:15 p.m. (Mon.)
Gronkowski’s fantasy owners may have the toughest decision this week. He missed last week with the back issue, but all indications are that he will be active for Week 8. Fantasy owners should start him with caution, however, as he is susceptible to re-injury. It wasn’t clear exactly what the back issue was (spasms could indicate a lot of things), but Gronk was able to put in a couple of limited practices this past week. Owners should plan to have him in Week 8, but be aware he may be limited.
LeSean McCoy (concussion), RB, Buffalo Bills vs. New England Patriots, Monday, 8:15 p.m.
Fantasy owners are going to have to make a tough call when it comes to McCoy. He may get cleared from the concussion protocol from anywhere between late Saturday to right up before kickoff... or he may not. Fantasy owners are going to have to be prepared to make a last-minute switch if needed. McCoy’s owners should also have Chris Ivory on the roster to be safe, but if not, waiting on McCoy may result in zero points as it’s impossible to tell if a player will pass the concussion protocol. If active, McCoy is a RB2.
Marlon Mack (ankle), RB, Indianapolis Colts at Oakland Raiders, 4:05 p.m.
Mack did practice in full on Friday, so fantasy owners should expect to see him out there in Week 8. While this is a later game, fantasy owners should be pretty confident that Mack will play. In Week 7, he had more than 100 rushing yards and two touchdowns (one rushing, one receiving). He looked good and the matchup against the Raiders is appealing. Mack is a solid RB2.
Matt Breida (ankle), RB, San Francisco 49ers at Arizona Cardinals, 4:25 p.m.
Breida is likely on the doubtful side of the questionable tag after missing practice both Wednesday and Thursday. He put in a limited session of Friday, which is why he's questionable. However, fantasy owners should know not to be fooled by Breida anymore. He’s left too many games with injury to be trusted, especially after a week where he barely practiced. The 49ers don’t have a bye until Week 11, so it would be wise on their (and fantasy owners') part to let Breida rest and give Raheem Mostert a chance to run the ball.
Chris Ivory (hamstring), RB, Buffalo Bills vs. New England Patriots, 8:15 p.m. (Mon.)
Even though Ivory was added to the injury report this week with a hamstring issue, he is expected to play. LeSean McCoy owners should have Ivory on their roster (handcuff your top running backs!), but if they don’t, Ivory will have value only if McCoy is out. This is a tough situation but assume that Ivory will play as McCoy's status likely won't be known until after the early Sunday games kick off (if not later).
Chris Thompson (ribs/knee), RB, Washington Redskins at New York Giants, 1 p.m.
Thompson hasn’t played since Week 5, dealing primarily with the ribs injury. He had been putting in limited practices, but he hasn’t been able to go on game day. It does seem that he will play this week, bringing Adrian Peterson’s value down a bit. Thompson is a low-end flex this week, as Peterson should still get most of the work.
— Written by Sarah Lewis, who is part of the Athlon Contributor network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.