It will be hard to trust Dalvin Cook even if he does play in Week 16
Fantasy owners who actually started Kenyan Drake were rewarded with four touchdowns and likely a victory in Week 15. While it is unlikely that he will do that again, it is clear that he is the running back to own and start for the Arizona Cardinals. Even though the Cardinals face the Seattle Seahawks in Week 16, he is still ranked as an RB2 (No. 21). Drake is likely playing for a contract, and the Cardinals are going to have to make some decisions at running back, so they will see what he can do.
Note that some injuries are going to play a role this week. Dalvin Cook (and Alexander Mattison) are not ranked. While Cook has said that he feels good, it's hard to trust him. As the week goes on, the rankings will be updated accordingly. In the meantime, Mike Boone is ranked No. 27. He's an RB3 if Cook is out. Also note that Kerryon Johnson is ranked at No. 42 as he is expected to return from injured reserve and play this week. There is a chance he doesn't end up playing, and fantasy owners shouldn't trust him in their fantasy championship.
NFL RB Rankings: Week 16
— Rankings by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.