Fantasy owners of Christian McCaffrey and Aaron Jones had a very nice week in Week 5. Both backs are in the top six again for Week 6. While Jones likely won't score four touchdowns, McCaffrey has at least 100 yards from scrimmage in four of the five games so far this season. The Panthers face the Buccaneers, who allow the second-fewest fantasy points to opposing running backs. These two teams already faced each other once this season, and that was the one game where McCaffrey had single-digit fantasy points (37 rushing yards and 16 receiving yards). He's ranked No. 2 this week, but fantasy owners should be wary.
The running back waiver wire is a bit bare, so just look to make sure you have your stud running back's handcuff (Chase Edmonds, in particular). Keep an eye on running backs who may be a little banged up. Saquon Barkley may end up playing on Thursday night but don't count on it. If he returns, he is the No. 12 running back this week. Melvin Gordon returned and had more carries than Austin Ekeler in Week 5. However, Ekeler has a large role in the passing game. Both running backs are in the top 20, and Ekeler has more value in PPR formats.
Teams on bye: Buffalo, Chicago, Indianapolis, Oakland
NFL RB Rankings: Week 6
— Rankings by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.