Heading into Week 1, fantasy owners are going to have to make some difficult start and sit decisions. These decisions are going to be tougher than usual because we haven't seen anyone play in an NFL game yet this year. When it comes to quarterbacks, tight ends, and defense/special teams (DSTs), fantasy owners may have only drafted one of each of these, so their start/sit decisions are easy. Don't go running to the waiver wire just yet. Take the one that you drafted, as you must have had a reason to do so, and start them. Trust your original instinct. Don't get cute. Just go with what you think and what you thought... and hope for the best.
START These Quarterbacks
Drew Brees, New Orleans Saints vs. Tampa Bay Buccaneers
Brees may be 41, but he gets to play at home in Week 1, where he historically does very well. In addition, the Saints face the Tampa Bay Buccaneers, who were one of the defenses to exploit through the air last year. While personnel changed a bit, this still should be a good match-up for Brees. He should be rested and late-season fatigue is obviously not going to be a factor. Fire up Brees and Michael Thomas for what should be a good Week 1.
Dak Prescott, Dallas Cowboys at Los Angeles Rams
Prescott had a career-best year in terms of yards last year, throwing for nearly 5,000 yards. He has great pass-catchers returning, and the team added CeeDee Lamb, who should make an impact early in the season. Between the solid wide receivers, Ezekiel Elliott, and even Blake Jarwin factoring in a bit, Prescott is set up to have another QB1 season. In Week 1, the Cowboys are at the Rams, and he should be in starting lineups.
SIT These Quarterbacks
Cam Newton, New England Patriots vs. Miami Dolphins
It will be odd to watch the New England Patriots without Tom Brady, but Newton will try to fill in. After barely playing in two games in 2019, Newton had surgery on his foot and his shoulder is supposedly healed. There haven't exactly been glowing reports out of Patriots camp, but they are also are known to keep things under wraps. Either way, it would be a risk to trust Newton for Week 1.
Baker Mayfield, Cleveland Browns at Baltimore Ravens
For two years, the hype has surrounded Mayfield as someone to watch who may break out. That continues into year three, but the breakout is not likely to occur in Week 1. The Browns face the Ravens, in Baltimore. Mayfield still has Odell Beckham Jr. and a still-healing Jarvis Landry to throw to, but expect the running backs to try to move the ball in this one. Mayfield should only be started in two-QB leagues.
START This Tight End
George Kittle, San Francisco 49ers vs. Arizona Cardinals
With both Deebo Samuel and Brandon Aiyuk banged up and likely questionable for Sunday's game, the 49ers are going to need someone to throw to. Even if either Samuel or Aiyuk plays, they will likely be limited. Kendrick Bourne is the wide receiver most likely to play and see the most targets, but odds are that Jimmy Garoppolo will look to Kittle and the running backs to move the ball in Week 1. Start him in all formats, including DFS.
SIT This Tight End
Austin Hooper, Cleveland Browns at Baltimore Ravens
Because teams have not yet played a real game, it may be hard to trust a tight end that is new to the team. While Hooper had a great season in Atlanta, there may be some rust in Week 1. He is working with a new quarterback, and while they have worked together in the off-season, it is different in a real game. The Browns face the Ravens, who had a tough defense last year and will likely continue to be formidable in 2020. Hooper has the potential to be a TE1 some weeks, but not Week 1.
START This Defense/Special Teams (DST)
Chicago Bears at Detroit Lions
The Chicago DST was solid last year, and that should continue this year. The Bears face the Detroit Lions in Week 1, and while they are in Detroit, the Lions are banged up. The wide receivers have been limited with soft tissue injuries. The running backs are newly-signed Adrian Peterson, banged up D'Andre Swift, and Kerryon Johnson (who clearly is not trusted by the organization). The offense is going to struggle and the Bears are likely going to capitalize.
SIT This Defense/Special Teams (DST)
Seattle Seahawks at Atlanta Falcons
The Seahawks fly across the country to face Atlanta in Week 1. The Falcons are a team that usually plays better at home than on the road, and the Seahawks are a defense that is usually better at home than on the road. The combination makes the Seahawks DST tough to trust in Week 1. While it is certainly difficult to judge a DST prior to Week 1, the Seattle DST isn't one to wager on this week.
— Rankings by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.