Fantasy owners have easier decisions for Week 2 to make when it comes to running backs than when it comes to the wide receivers. For one, there are fewer injuries to fantasy-relevant players. Second, some running backs (and tight ends) have already been placed on injured reserve, so they are definitely out (some for the season, such as Marlon Mack and Blake Jarwin). Le'Veon Bell is one example of a running back that is going to miss some time, so the team placed him on IR, but he is eligible to return in three weeks.
Always be sure to check the status of your players before submitting your lineup. Fantasy owners may have tough decisions to make when it comes to start/sit, but they should never start a player that has already been ruled out. Be sure to check the inactive report before game time, just to be sure.
Jack Doyle, TE, Indianapolis Colts
Darrynton Evans, RB, Tennessee Titans
George Kittle, TE, San Francisco 49ers
Phillip Lindsay, RB, Denver Broncos
Justin Jackson, RB, Los Angeles Chargers
Note: All times are ET and all games are on Sunday, Sept. 20.
Duke Johnson (ankle), RB, Houston Texans vs. Baltimore Ravens, 4:25 p.m.
Johnson had five carries and one target in Week 1. Granted, he did get injured and left the game, but he was not part of the game script even when he was healthy. With David Johnson now in the picture, the backfield belongs to him. Duke Johnson was used in the passing game in the past, but until Houston shows that he is part of that, he should be on fantasy benches.
LaMical Perine (ankle), RB, New York Jets vs. San Francisco 49ers, 1 p.m.
Perine, a rookie, missed Week 1 with an ankle injury, but he was able to get in a few limited practices this week. With Le'Veon Bell out, the Jets need all the help they can get at running back (Frank Gore and Josh Adams are currently going to carry the ball, with some Kalen Ballage mixed in). The Jets' running back situation is a mess and one to avoid for all fantasy purposes. Don't start Perine unless you’re truly desperate.
Justice Hill (thigh), RB, Baltimore Ravens at Houston Texans, 4:25 p.m.
Fantasy owners should not be planning on using Hill in any format. He's returning from a thigh injury and the backfield for the Ravens is already crowded. Until the team figures out who they want to use, it's going to be tough, but Hill is not in the mix at the moment.
Gerald Everett (back), TE, Los Angeles Rams at Philadelphia Eagles, 1 p.m.
Everett practiced in full on Friday, so fantasy owners don't need to be worried that he won't play. However, they should be worried about his lack of volume. He had two targets in Week 1 (catching one for seven yards). Meanwhile, Tyler Higbee had four targets (he caught three for 40 yards). It didn't help that Jared Goff only completed 20 passes (out of 31), but if you were to trust a Rams tight end, it wouldn't be Everett.
— Rankings by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.