Saquon Barkley, Christian McCaffrey and Tevin Coleman are three players that are now sidelined for at least three games (Barkley is out for the year with a torn ACL). Plenty of others are out this week while they are dealing with injuries as well. Look to their backups (and use this is an early sign to try to grab your star running back's handcuff).
Quarterbacks and tight ends had some injuries as well, although not as many as running back. It was a tough week and fantasy owners were likely active on the waiver wire to fill roster holes. As always, check the inactive report before game time to make sure your players are all active.
Cam Akers, RB, Los Angeles Rams
Jimmy Garoppolo, QB, San Francisco 49ers
George Kittle, TE, San Francisco 49ers
Drew Lock, QB, Denver Broncos
Zack Moss, RB, Buffalo Bills
Raheem Mostert, RB, San Francisco 49ers
Tyrod Taylor, QB, Los Angeles Chargers
James White, RB, New England Patriots
Justin Jackson, RB, Los Angeles Chargers
Phillip Lindsay, RB, Denver Broncos
Note: All times are ET and all games are on Sunday, Sept. 27.
Josh Jacobs (hip), RB, Oakland Raiders at New England Patriots, 1 p.m.
Jacobs went down a couple of times in Monday night's game and fantasy owners still reeling from Sunday's bloodbath may have been a little nervous. He did return to the game, but then proceeded to miss practice on Wednesday and Thursday. He returned on Friday, putting him on track to play in Week 3. He had 25 and 27 carries in the first two weeks, respectively and a total of 181 rushing yards and three touchdowns (all in Week 1). He should be fine as an RB1 for Week 3.
Darren Waller (knee), TE, Oakland Raiders at New England Patriots, 1 p.m.
After Waller likely won fantasy owners their matchups on Monday night, he didn't practice on Wednesday or Thursday. Coming off a game where he had 16 targets and caught 12 of them for 105 yards and a touchdown, he likely needed a little rest. Waller practiced on Friday and should be good to go against the Patriots in Week 3. However, expect the Patriots to try to shut him down, as they often try to focus on the team's top weapon. He's still a TE1, but don't expect Week 2 numbers.
Jack Doyle (ankle), TE, Indianapolis Colts vs. New York Jets, 4:05 p.m.
Doyle played in the opener (3/49/0 stat line) and then stat in Week 2 with an ankle injury. He was able to return to practice on Thursday and Friday, which puts him in line to play Sunday afternoon. The Colts face the Jets, which isn't a bad matchup, but it's going to be hard to trust Doyle coming back from injury. He's a TE2 for fantasy owners that need to start two tight ends.
Duke Johnson (ankle), RB, Houston Texans at Pittsburgh Steelers, 1 p.m.
Most fantasy owners are not starting Duke Johnson, but if he is active, David Johnson may have less work. In a sense, it doesn't matter all that much, because the David Johnson fantasy owners are starting him as an RB1, and Duke Johnson should stay on the bench. David Johnson had the exact same number of targets and carries in Week 2 (with Duke Johnson out) than in Week 1. Start David, sit Duke.
— Written by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.