While the number of wide receiver injuries heading into Week 5 is the highest that it’s been all season, other positions have injuries that fantasy owners need to monitor. Quarterbacks Cam Newton, Sam Darnold and Mitchell Trubisky have already been ruled out. Tight ends Jordan Reed, Vernon Davis, and Ben Watson have been ruled out. Running backs Saquon Barkley, Rex Burkhead, and Jamaal Williams have been ruled out. Also, fantasy owners should note that Stephen Gostkowski was placed on injured reserve (and the Patriots signed Mike Nugent to replace him). Get him out of your lineups. As always, be sure to check the inactive reports before game time.
Teams on bye: Detroit, Miami
Note: All times are ET and all games are on Sunday, Oct. 6 unless otherwise noted.
Damien Williams (knee), RB, Kansas City Chiefs vs. Indianapolis Colts, 8:20 p.m.
After practicing all week, Williams is definitely on track to play Sunday night. He's missed the past two weeks, but he should be good to go in Week 5. LeSean McCoy will still have a role, but Darrel Williams will now lose his fantasy value. Damien Williams is an RB2.
Marlon Mack (ankle), RB, Indianapolis Colts at Kansas Chiefs, 8:20 p.m.
Mack did play in Week 4 but left the game with an ankle injury and didn't return. He missed practice on Wednesday and Thursday before returning for a full session on Friday. It seems likely that he'll play on Sunday night, but fantasy owners should be concerned with his workload. If this game ends up being close or if the Chiefs take a lead, Mack's role will diminish. The Colts have already shown that they prefer Nyheim Hines when playing from behind (passing situations). Mack is an RB3 if active.
Tevin Coleman (ankle), RB, San Francisco 49ers vs. Cleveland Browns, 8:15 p.m. (Mon.)
Coleman hasn't played since Week 1, but all signs point to him finally getting back out there on Monday night. This is tough for fantasy owners as waiting until Monday night makes a start/sit decision difficult. Keeping that in mind, along with the fact that Raheem Mostert, Jeff Wilson Jr., and Matt Breida are all in the mix, Week 5 might be a good time to sit Coleman. Wait to see how this RB logjam shakes out.
Vance McDonald (shoulder), TE, Pittsburgh Steelers vs. Baltimore Ravens, 1 p.m.
After missing practice this week, it seems that McDonald will likely sit out another game. He missed Week 4, and he's lost quite a bit of his fantasy appeal. Even though it would make sense for Mason Rudolph to use his tight ends as a safety blanket, it’s clear he prefers to throw to his running backs. McDonald, if active, is a low TE2.
Devin Singletary (hamstring), RB, Buffalo Bills at Tennessee Titans, 1 p.m.
After missing the last two weeks, Singletary is a game-time decision for Week 5. The Bills have a bye in Week 6, so if they want to be cautious, they could just keep him sidelined for another week. Frank Gore has done well with Singletary out, and the Bills may just rely on him for another week. If Singletary is active, he’s an RB3.
— Written by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.