As the weeks go on, more and more fantasy-relevant players find their way onto the injury report. Fantasy owners often get a little nervous when their starting players are questionable and have limited practices throughout the week.
With four teams on bye, fantasy owners have a smaller pool to choose from. Running backs who have been ruled out include Todd Gurley, Jaylen Samuels, and Darren Sproles, while Justin Jackson is doubtful. Cam Newton and Mason Rudolph are quarterbacks who have been ruled out. Tight ends Chris Herndon, Jordan Reed (went on injured reserve this week), Vernon Davis, and Josh Oliver are out as well.
Don't forget about the key injured wide receivers and the early (9:30 a.m. ET) game in London this week. As always, check the inactive report before game time
Teams on bye: Buffalo, Chicago, Indianapolis, Oakland
Note: All times are ET and all games are on Sunday, Oct. 13 unless otherwise noted.
Alvin Kamara (ankle), RB, New Orleans Saints at Jacksonville Jaguars, 1 p.m.
Kamara picked up an ankle injury in practice on Thursday and did not take part in Friday's session. He was given a questionable tag, but it does seem that the Saints may limit his touches in Week 6. Kamara's backup is Latavius Murray, who hasn't had much of a fantasy presence this season. Kamara should still be started as an RB1, assuming he's active, but Murray steps up to an RB3 this week with the opportunity to pick up additional touches.
David Johnson (back), RB, Arizona Cardinals vs. Atlanta Falcons, 4:05 p.m.
After Johnson said his back locked up in Week 5, he missed practice on Wednesday and Thursday. Fantasy owners frantically picked up Chase Edmonds with the hope that if Johnson was out, Edmonds would take over. Now it seems that Johnson will be active for Week 6. Those that grabbed Edmonds now have to decide how much of a role they think he'll have. Johnson will likely play, but chances are the workload will be split between him and Edmonds, which is not a good thing to deal with in fantasy.
Rashaad Penny (hamstring), RB, Seattle Seahawks at Cleveland Browns, 1 p.m.
Penny was a late addition to Thursday's injury report. It seems that Penny may be a game-time decision for Week 6. Fantasy owners should monitor the inactive report, but thankfully this is an early game. Chris Carson will be the No. 1 back, and Penny's fantasy owners should keep him on the bench if at all possible. Even if he's active, he will take a backseat to Carson.
George Kittle (groin), TE, San Francisco 49ers at Los Angeles Rams, 4:05 p.m.
Unfortunately for fantasy owners, Kittle looks to be a game-time decision with a groin injury he picked up late in the week. He put in a limited practice on Friday, which usually is an indicator that a player will suit up on Sunday. Fantasy owners need to be careful, as Kittle is in the late afternoon slate of games. It will be hard to sit him, so fantasy owners should take a chance and keep Kittle in lineups. However, they should also keep an eye on the waiver wire, just in case they need to pick someone up from the later games.
Hunter Henry (knee), TE, Los Angeles Chargers vs. Pittsburgh Steelers, 8:20 p.m.
Four and a half weeks ago, Henry suffered a tibia plateau fracture to his knee. This usually comes with a recovery time of four to six weeks. While it's not uncommon for players to beat their recovery time, Henry also is coming off a torn ACL. He did practice in full on Friday, which usually bodes well for playing in the game, but the Chargers may still take it slow with their tight end. If Henry is active, and it seems he will be, he will likely see limited snaps. He's a risky fantasy play this week.
Mark Andrews (shoulder), TE, Baltimore Ravens vs. Cincinnati Bengals, 1 p.m.
Andrews has been on the injury report with a foot injury. This week, the foot injury didn't appear in the injury designation, but rather a shoulder. He did go down with an injury during Week 5, but was able to return to the game. He was able to practice and will play in Week 6. He's a TE1 in a decent matchup. With Marquise Brown banged up and possibly out as well, the Ravens are going to need him.
T.J. Hockenson (concussion), TE, Detroit Lions at Green Bay Packers, 8:15 p.m. (Mon.)
After Hockenson suffered a concussion in Week 4, he had the Week 5 bye to recover. He has been able to practice, but he has yet to get full clearance. The team expects/hopes that he'll have that by Monday, but this makes it tough for fantasy owners. If somehow, fantasy owners hear that he has cleared the concussion protocol earlier, keep him in your lineup. Otherwise, while it's likely that Hockenson will play and is a TE2, the uncertainty makes this a risky wager.
— Written by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.