Each week during the NFL season, we will rank enough players at each position to appease everyone from those in 8-team leagues to 16-team leagues, those that can start two QBs, two TEs, three RBs and four WRs. We cut out the rest, because if you're looking at who the 50th-best running back or the 17th-best kicker is for that week, you need more help than any Web site can give you.
Arizona, Cleveland, Green Bay and Washington are all on bye this week.
2012 NFL Week 10 Fantasy Football Rankings — Quarterbacks
| Rk | Player | Team | OPPONENT | Notes |
| 1 | Tom Brady | NE | vs. BUF | Tom Terrific is 19-2 vs. Bills w/ 49 TD passes. |
| 2 | Peyton Manning | DEN | at CAR | Came up just 9 yards shy of 5th 300-3 game in a row. |
| 3 | Drew Brees | NO | vs. ATL | Has thrown for 15 TDs vs. 3 INTs in last five games. |
| 4 | Matt Ryan | ATL | at NO | Threw for 342 yards, but no TDs (or INTs) vs. Dallas. |
| 5 | Ben Roethlisberger | PIT | vs. KC (Mon.) | Only two games with 300+ yards, but 16 TDs. |
| 6 | Andrew Luck | IND | at JAC (Thurs.) | Posted NFL rookie record 433 yards last week. |
| 7 | Matthew Stafford | DET | at MIN | Only eight TD passes in eight games so far. |
| 8 | Eli Manning | NYG | at CIN | Only 2 TDs w/ 4 INTs in last four games. |
| 9 | Cam Newton | CAR | vs. DEN | Total TDs after 8 games: 18 in '11 vs. 10 in '12. |
| 10 | Josh Freeman | TB | vs. SD | Has 11:1 TD:INT ratio over last four games. |
| 11 | Michael Vick | PHI | vs. DAL | Has 11:3 TD:INT ratio in 6 career games vs. Dallas. |
| 12 | Tony Romo | DAL | at PHI | Nine of his 13 INTs were thrown in two games. |
| 13 | Carson Palmer | OAK | at BAL | Posted fifth career 400-yard game last week. |
| 14 | Ryan Fitzpatrick | BUF | at NE | Put up 350-4-4 in Week 4 loss to Patriots. |
| 15 | Philip Rivers | SD | at TB | Tampa Bay last in league (321 ypg) in pass defense. |
| 16 | Joe Flacco | BAL | vs. OAK | Less than 200 yards passing in 3 of last 4 games. |
| 17 | Andy Dalton | CIN | vs. NYG | Giants 26th against pass, allowing 264 ypg. |
| 18 | Alex Smith | SF | vs. STL | Tied season high with 3 TD passes in last game. |
| 19 | Ryan Tannehill | MIA | vs. TEN | Played through injury, put up 290-1-0 vs. Colts. |
| 20 | Matt Schaub | HOU | at CHI | Bears are 4th in sacks, tied for 1st in INTs. |
| 21 | Jay Cutler | CHI | vs. HOU | Texans are No. 4 against pass, tied for 6th in sacks. |
| 22 | Jake Locker | TEN | at MIA | Will resume his starting job, barring a setback. |
| 23 | Russell Wilson | SEA | vs. NYJ | Has yet to throw an INT at home. |
| 24 | Sam Bradford | STL | at SF | Comes off of bye to face league's No. 2 pass defense. |
| 25 | Blaine Gabbert | JAC | vs. IND (Thurs.) | Tied season high with 2 TD passes vs. Lions. |
| 26 | Mark Sanchez | NYJ | at SEA | Seahawks have allowed only 3 TD passes at home. |
Rankings are based upon Athlon Sports' standard scoring system:
OFFENSIVE SCORING
All touchdowns are 6 points
1 point for 25 yards passing
1 point for 10 yards rushing/receiving
Receptions are .5 points
Interceptions/fumbles are minus-2 points
Additional Week 10 Positional Rankings
Running Backs
Wide Receivers
Tight Ends
Kickers
Defense/Special Teams
