Each week during the NFL season, we will rank enough players at each position to appease everyone from those in 8-team leagues to 16-team leagues, those that can start two QBs, two TEs, three RBs and four WRs. We cut out the rest, because if you're looking at who the 50th-best running back or the 17th-best kicker is for that week, you need more help than any Web site can give you.
Arizona, Cleveland, Green Bay and Washington are all on bye.
2012 NFL Week 10 Fantasy Football Rankings — Running Backs
| Rk | Player | Team | OPPONENT | Notes |
| 1 | Ray Rice | BAL | vs. OAK | Rookie Doug Martin gashed Raiders for 251 last week. |
| 2 | Adrian Peterson | MIN | vs. DET | All Day is leading the league in rushing. |
| 3 | Marshawn Lynch | SEA | vs. NYJ | Beast mode could be in effect vs. No. 27 rush defense. |
| 4 | LeSean McCoy | PHI | vs. DAL | Averaging 96 rushing yards per game over last four. |
| 5 | Arian Foster | HOU | at CHI | Faces tough task against No. 6 rush defense. |
| 6 | Doug Martin | TB | vs. SD | Rookie has 386 rushing yards, 5 TDs in last two games. |
| 7 | Stevan Ridley | NE | vs. BUF | Bills giving up league-worst 5.7 ypc. |
| 8 | Willis McGahee | DEN | at CAR | Averaging 20+ attempts over last three games. |
| 9 | Frank Gore | SF | vs. STL | Sore ribs shouldn't be an issue coming off of bye. |
| 10 | Matt Forte | CHI | vs. HOU | Texans have yet to allow rushing TD. |
| 11 | Reggie Bush | MIA | vs. TEN | Titans are allowing 141.6 yards rushing per game. |
| 12 | Chris Johnson | TEN | at MIA | CJ (141, TD) lone Titans bright spot last week vs. Bears. |
| 13 | Jamaal Charles | KC | at PIT (Mon.) | Has 83 yards rushing in last three games combined. |
| 14 | Ryan Mathews | SD | at TB | Bucs are No. 1 in league against rush (77.3 ypg). |
| 15 | Michael Turner | ATL | at NO | Posted second 100-yard game vs. Cowboys. |
| 16 | Ahmad Bradshaw | NYG | at CIN | Averaging only 56.3 ypg over last three. |
| 17 | C.J. Spiller | BUF | at NE | Averaging 7.2 yards per carry. |
| 18 | Rashad Jennings | JAC | vs. IND (Thurs.) | Colts allowing seventh-most fantasy points to RBs. |
| 19 | Mikel Leshoure | DET | at MIN | Leshoure had just 70 yards, but 3 TDs vs. Jaguars. |
| 20 | BenJarvus Green-Ellis | CIN | vs. NYG | Season-best 91 yards rushing came back in Week 1. |
| 21 | Isaac Redman | PIT | vs. KC (Mon.) | Should get another start after 147-yard effort vs. Giants. |
| 22 | Vick Ballard | IND | at JAC (Thurs.) | Donald Brown's health dictates Ballard's workload. |
| 23 | Shonn Greene | NYJ | at SEA | Hoping to get Ground and Pound going coming off of bye. |
| 24 | Pierre Thomas | NO | vs. ATL | His role increases if Sproles (hand) is out. |
| 25 | Steven Jackson | STL | at SF | San Francisco is No. 5 in league vs. rush. |
| 26 | Fred Jackson | BUF | at NE | Longest rush thus far has been just 13 yards. |
| 27 | Jonathan Stewart | CAR | vs. DEN | Broncos are ninth in the league in rush defense. |
| 28 | Felix Jones | DAL | at PHI | Saw Lance Dunbar cut into carries last week. |
| 29 | Marcel Reece | OAK | at BAL | Should have impact in the Raiders' passing game. |
| 30 | Daniel Thomas | MIA | vs. TEN | Averaging 10 carries over last three games. |
| 31 | Andre Brown | NYG | at CIN | Bradshaw's lingering foot mean more work for Brown. |
| 32 | Darren Sproles | NO | vs. ATL | DNP last week (hand surgery), may be back vs. Falcons. |
| 33 | Joique Bell | DET | at MIN | Making an impact as both rusher and receiver. |
| 34 | DeAngelo Williams | CAR | vs. DEN | Fewer touches, but scored TD last week on 30-yard run. |
| 35 | Mark Ingram | NO | vs. ATL | Saw more carries with Sproles sidelined. |
| 36 | Jonathan Dwyer | PIT | vs. KC (Mon.) | Expected to be back this week. |
| 37 | Chris Ivory | NO | vs. ATL | His role is dependent upon Sproles' health. |
| 38 | Daryl Richardson | STL | at SF | Has gotten 7+ carries in four straight games. |
| 39 | Jacquizz Rodgers | ATL | at NO | Has been more active in passing game recently. |
| 40 | Danny Woodhead | NE | vs. BUF | Second on team in carries, 4th in receptions. |
| 41 | Taiwan Jones | OAK | at BAL | His workload is dependent on Goodson's ankle. |
| 42 | Kendall Hunter | SF | vs. STL | Total of 19 carries in past two games. |
| 43 | Mike Goodson | OAK | at BAL | Next up after McFadden, but he also has ankle injury. |
| 44 | Peyton Hillis | KC | at PIT (Mon.) | |
| 45 | Michael Bush | CHI | vs. HOU | Doesn't get many chances if it's not a blowout. |
| 46 | Donald Brown | IND | at JAC (Thurs.) | Listed as Questionable, but played vs. Dolphins. |
| 47 | Ronnie Hillman | DEN | at CAR | |
| 48 | Ronnie Brown | SD | at TB | Role has increased over past four games. |
Rankings are based upon Athlon Sports' standard scoring system:
OFFENSIVE SCORING
All touchdowns are 6 points
1 point for 25 yards passing
1 point for 10 yards rushing/receiving
Receptions are .5 points
Interceptions/fumbles are minus-2 points
Additional Week 10 Positional Rankings
Quarterbacks
Wide Receivers
Tight Ends
Kickers
Defense/Special Teams
