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Betting Against the Spread: NFL Week 2 Picks and Odds

Cam Newton

Cam Newton

It's Week 2 in the NFL and time to overreact to everything we've seen! Carson Wentz is going to win MVP while Josh Norman is the worst NFL free-agent signing of all-time. Seriously though, we have a little bit of an idea with some of these teams and now we can start making situational plays, which treated me so well last year.

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Record: 2-1

(All games are on Sunday and all times ET, unless otherwise noted)

San Francisco 49ers (1-0) at Carolina Panthers (0-1), 1 p.m.

I absolutely detest laying huge numbers in the NFL, but this game screams doing so. The 49ers picked up a home win on a late Monday night game against the Rams. San Francisco’s defense played really well in the victory (something not often said of a Chip Kelly-coached team), but it was facing Case Keenum. Carolina has had some extra time to stew after a very tough loss in Denver. The Panthers’ offense should be able to move the ball against San Francisco, which might be a little too high after beating LA. The Panthers have covered in 13 of their last 19 home games and five of their last six against the NFC West. SELECTION: Panthers -13

NFL Power Rankings: Panthers
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Indianapolis Colts (0-1) at Denver Broncos (1-0), 4:25 p.m.

The Broncos’ defense continued its stellar play, holding the Panthers to 20 points last Thursday. Denver has had extra time to prepare for the one-dimensional Colts, which lost a high-scoring affair to the Lions on Sunday. Indy may find things difficult on the road in this one. Trevor Siemian had a decent debut, but he was really helped by C.J. Anderson on the ground. Denver has a big matchup in Week 3 at Cincinnati. I think the Broncos win this one easily, but the score may be lower than anticipated. The last time these two teams played in Denver, the Colts won 24-13 back in 2015. The under has hit in exactly half of the last 20 home games for the Broncos. SELECTION: Under 45.5

Atlanta Falcons (0-1) at Oakland Raiders (1-0), 4:25 p.m.

I'm going to go against the money move on this one, which makes me uneasy. A lot of people are throwing their cash on the Falcons, which I don't get. Atlanta is 7-9 in its last 16 road games, covering in just six of them. The Falcons just lost as a favorite at home against the Buccaneers so what is inspiring other people's confidence? I wonder if it was the poor effort by Oakland's defense in New Orleans, but a lot of squads have struggled in that dome. Oakland's offense showed some balance with 167 rushing yards and 319 passing yards. The Falcons’ defense isn't that much better than the Saints. There aren't a lot of ATS numbers that help me and my Raiders pick. I'll fade Atlanta outside the dome whenever I can. SELECTION: Oakland -4.5

NFL Power Rankings: Raiders


— Minnesota is opening up its brand-new stadium on Sunday night for an NFC North clash against hated division rival Green Bay. The road team has won three straight in this series and the Packers are favored to make it four. The Vikings are 25-9 against the spread the last three seasons including 14-5 as an underdog. That is something to consider when looking at this matchup, although the questions at quarterback for the Vikings are also a factor. Strong lean to the under.

— The road team has won four of the last five meetings between the Bengals and Steelers. Pittsburgh looked dominant against the Redskins on Monday night, but has a short week to prepare for a divisional rival that edged the Jets in New York. Cincy has covered in 10 of its last 14 as an underdog.

— Written by Matt Josephs, who is a part of the Athlon Sports Contributor Network. Josephs prefers non-Power 5 college football and may be the only one wagering on the Sun Belt. Follow him on Twitter @MidMajorMatt.