No teams are on bye in Week 12, but one significant injury and matchups have a big impact on the fantasy quarterback rankings. Four of the top five are playing on the road, which is always tough. Ben Roethlisberger, in particular, has vastly different home and away stats. He is at Indianapolis this week, which is why he checks in near the bottom of the top 10. And if you have Andrew Luck you may as well starting looking at a different option because it would be a surprise if he plays Thanksgiving night.
Drew Brees, who is back home where he prefers, is No. 2 this week. Los Angeles is a pretty good defense, but Brees usually comes through for both the Saints and his fantasy owners when he’s in the Mercedes-Benz Superdome. Tom Brady is coming off of a four-touchdown game in San Francisco and usually gives the Jets fits. Even though this game is in the Big Apple, Tom Terrific is our No. 1 option for Week 12.
— Rankings by Sarah Lewis, who is part of the Athlon Contributor network and lives, eats, and breathes fantasy football. She also writes for SoCalledFantasyExperts.com among other sites. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.