We did take an early at some of the big-name players that were injured heading into Week 2 on Thursday, but now we have an official list of the running backs (and one quarterback) that may affect your fantasy lineup decisions heading into the 1 p.m. ET kickoffs on Sunday. Some of these ball carriers are likely to play, others may end up being the dreaded game-time decision, and a few have already been ruled out.
LeSean McCoy, RB, Buffalo Bills vs. New England Patriots
Questionable – Hamstring
McCoy played through his hamstring injury in Week 1 and looked okay. He put up 87 total yards, but he suffered a setback on Thursday and left practice early. McCoy had a limited practice on Friday and the word out of Buffalo is that he'll play. However, know this is a risky situation as he may suffer a setback during the game. Start him if he's active, but try to grab Karlos Williams as a handcuff in case he doesn't play.
C.J. Spiller, RB, New Orleans Saints vs. Tampa Bay Buccaneers
Questionable - Knee
After missing Week 1, Spiller may play today. He had a surgical procedure done on his knee during the preseason. He did put in limited practices this week, which typically puts a player on track to play on Sunday. However, since he has been out, his role may be smaller than usual. Mark Ingram will still be in for a big role as Spiller is eased back in the offense. He's a low RB3 for Week 1.
Tre Mason and Todd Gurley, RBs, St. Louis Rams at Washington Redskins
Questionable – Thigh, Questionable – Knee
Both running backs are questionable this week, although it looks like Mason will play and Gurley will sit. Benny Cunningham's value takes a hit if Mason does play. If both Mason and Gurley play, Cunningham is a RB2. If Mason plays, he's a RB2. If Gurley plays he likely will be on limited snaps, so leave him on the bench for another week to see how this RBBC shakes out.
Andre Ellington, RB, Arizona Cardinals at Chicago Bears
Out – Knee
Ellington injured his PCL in Week 1 and the original reports were that he was day-to-day. However, given Ellington's injury history and the nature of a PCL injury, it seemed likely he would miss Week 2. It is possible he misses Week 3 as well; watch the practice reports for more information in the coming week. Chris Johnson will be the lead back with David Johnson taking some carries as well. Chris Johnson is a RB2; David Johnson is a RB3.
Reggie Bush, RB, San Francisco 49ers at Pittsburgh Steelers
Out – Calf
Bush has already been ruled out for Week 2, leaving the door open for Carlos Hyde to have another big week against the Steelers. Bush says he'll play in Week 3, but watch the practice reports this week.
Josh McCown, QB, Cleveland Browns
Out – Concussion
McCown has been ruled out for Week 2, leaving Johnny Manziel to start the game. Ignore as much of the Browns’ offense for fantasy purposes as you can.
— Written by Sarah Lewis, who is part of the Athlon Contributor network and lives, eats, and breathes fantasy football. She also writes for SoCalledFantasyExperts.com among other sites. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.