It didn't seem that Week 6 would have a lot of injuries affecting the fantasy rankings and player start/sit decisions. However, owners may have to deal with not having Todd Gurley, David Johnson and/or Davante Adams this week.
This opens the door for some (hopefully rostered) backups. It’s always hard to make lineup decisions, but fantasy owners need to be sure they are keeping an eye on the injury reports throughout the week. Pick up players as needed, even if you don't own the starter. This will prevent your opponent from getting them and playing them against you.
Please note 5 Up/5 Down is a guide on players that should exceed or fall below their rank this week. This is based on past performance, injury status, and matchup. This is not a start/sit column, but rather a guide.
Teams on bye: Buffalo, Chicago, Indianapolis, Oakland
Dak Prescott, QB, Dallas Cowboys
After a loss to Green Bay in Week 5, the Cowboys are going to be looking to get a win. They face the New York Jets, who allowed at least 250 passing yards to opposing quarterbacks in the first three games. Carson Wentz struggled a bit against them last week but still scored a touchdown. With Michael Gallup back, Prescott has another weapon to use. He’s thrown for more than 400 yards twice this season. While he may not get to 400 yards in Week 6, he should exceed his No. 12 ranking.
Matt Breida, RB, San Francisco 49ers
Even with Tevin Coleman back in Week 5, Breida had 11 carries. With those carries, he ran for 114 yards and a touchdown. He added three receptions on three targets for 15 yards and a touchdown. While he may not have a game that big again in Week 6 against the Rams, Breida should exceed his No. 25 ranking.
Dede Westbrook, WR, Jacksonville Jaguars
It’s been D.J. Chark Jr. who has been Gardner Minshew’s favorite target, but Westbrook shouldn’t be forgotten about. It’s possible that Saints CB Marshon Lattimore will shadow Chark, which is great news for Westbrook. Mike Evans was shut down entirely in Week 5, thanks to Lattimore. Instead, Chris Godwin had seven receptions for 125 yards and two touchdowns. Westbrook is ranked No. 41, but is a WR3 this week.
Terry McLaurin, WR, Washington Redskins
In a game between two bad teams, someone is going to do well. Odds are that for Washington, that person is McLaurin. He’s been a bright spot in the Redskins' offense, scoring a touchdown in three of the four games he’s played. The Dolphins have allowed plenty of yards and touchdowns to opposing wide receivers this year and McLaurin should exceed his No. 29 ranking.
Gerald Everett, TE, Los Angeles Rams
Everett had 11 targets in Week 5 and eight in Week 4. He found the end zone in Week 4 as well. Yet, somehow Everett has gotten lost in the Rams' offense. After 136 receiving yards in Week 5, he should be on the tight end radar. Brandin Cooks and Todd Gurley are both questionable mid-week, and if either of them were to miss the game Everett might have an even bigger role. San Francisco has been tough against tight ends, but they haven’t faced many great ones. Not that Everett is great, but he should exceed his No. 13 ranking.
Jimmy Garoppolo, QB, San Francisco 49ers
Garoppolo has had a couple of games that fantasy owners were happy with — Week 2 where he threw for three touchdowns and he had two in Week 5. However, even in Week 5, he only threw for 181 yards. The 49ers have turned into a run-first offense. Garoppolo has been a decent quarterback, but when the offense calls for Matt Breida, Tevin Coleman and even Raheem Mostert to run the ball, Garoppolo doesn’t have to do a lot. He’s ranked No. 16 for Week 6 against the Rams, but he’s a QB2.
Joe Mixon, RB, Cincinnati Bengals
Mixon has yet to have a 100-yard rushing game or a rushing touchdown this year. He had a receiving touchdown in Week 3, but he hasn’t been the RB1 that fantasy owners may have drafted him as this year. He’s ranked No. 19 this week, but the Baltimore run defense is decent. He’s a low RB2 with the hope that he’ll find the end zone. Baltimore gave up a huge game to Nick Chubb, but the Ravens have defended other running backs fairly well.
Phillip Lindsay, RB, Denver Broncos
Both Lindsay and Royce Freeman have been splitting touches for the Broncos, bringing each other’s fantasy value down. Lindsay is ranked No. 18 this week, following a 114-yard, TD performance with 33 receiving yards. He has a tough matchup against the Titans this week. They have only allowed two touchdowns to opposing running backs. It’s hard to say which back will be featured this week, but Lindsay should be viewed as a low RB2.
Will Fuller, WR, Houston Texans
In Week 5, Fuller had 14 receptions for 217 yards and three touchdowns. There’s nowhere to go but down! Fuller is a clear downfield threat, but that kind of production likely isn’t going to come again. The Texans face the Kansas City Chiefs, and their defense has been decent against the pass. They haven’t allowed 100 yards to an opposing wide receiver since Week 1. Fuller is ranked No. 22 because of his big game last week, but he’s a WR3.
O.J. Howard, TE, Tampa Bay Buccaneers
With no more than four receptions in a game and a season-high of 66 yards, Howard has been a fantasy disappointment. He hasn’t found the end zone, and while one of these games he’ll likely break out, it’s unlikely to be Week 6. He’s ranked No. 11, but he’s facing a Panthers defense that has allowed one touchdown to a tight end (Week 1) and hasn’t allowed more than 57 yards to the position this season.
Full Disclosure for Week 5
5 Up (2/5 correct)
Andy Dalton, QB, and Bengals (Ranked: 15, actual: 10)
Jaylen Samuels, RB, Steelers (Ranked: 33, actual: outside the top 50)
Geronimo Allison, WR, Packers (Ranked: 33, actual: outside the top 50)
Courtland Sutton, WR, Broncos (Ranked: 36, actual: 13)
Jack Doyle, TE, Indianapolis Colts (Ranked: 17, actual: 29)
5 Down (4/4 correct, one inactive)
Aaron Rodgers, QB, Packers (Ranked: 7, actual: 22)
LeSean McCoy, RB, Chiefs (Ranked: 17, actual: outside the top 50)
Wayne Gallman, RB, Giants (Ranked: 24, actual: outside the top 50)
Tyrell Williams, WR, Raiders (Ranked: 24, actual: inactive)
Delanie Walker, TE, Titans (Ranked: 10, actual: 39)
— Rankings by Sarah Lewis, who is part of the Athlon Contributor Network and lives, eats, and breathes fantasy football. Have a fantasy football question? Send it to her on Twitter @Sarah_Lewis32.