One of the biggest threads between these Week 2 games is the interesting quarterback matchups. Four games feature pairings of teams with new QBs, and two are facing their former teams. Another game features a duel of rookie signal-callers.
There are also three different games between playoff teams from last season — and they're spread out. The Rams and Colts will meet at 1 p.m., while the Titans and Seahawks will face off in the late afternoon before Kansas City and Baltimore face off on "Sunday Night Football."
So if you're wondering "What NFL games are on today?" know this: There are 14 scheduled for today, Sunday, Sept. 19.
Note: Games are ordered by start time. All times are ET.
NFL Games on TV Today
New England at New York Jets, 1 p.m. on CBS
Rookie quarterbacks Mac Jones and Zach Wilson are off to 0-1 starts to begin their NFL careers, and this will be their first of many meetings. Pressure will be on New England, who hasn't lost to the Jets in 10 games, and even that last loss was in overtime.
New Orleans at Carolina, 1 p.m. on CBS
Jameis Winston and Sam Darnold were successful in their first career starts for their respective NFC South teams. Amazingly, after throwing a combined 57 interceptions in 41 starts the last two years, neither threw a pick in Week 1. Will that change in Charlotte?
Cincinnati at Chicago, 1 p.m. on FOX
For the second time in six games, Andy Dalton will be facing off against his former team. Then with the Cowboys, he got the better of the Bengals in 2020, but now Cincinnati will have a healthy Joe Burrow.
Houston at Cleveland, 1 p.m. on CBS
The Texans shocked many when they walloped the Jaguars in Week 1, but they're still the biggest underdog of the week on Sunday. We'll see what Tyrod Taylor has under his sleeves as he also faces off against his former team.
Los Angeles Rams at Indianapolis, 1 p.m. on FOX
Both the Rams and Colts debuted new quarterbacks last week — to different results, however. LA looked nearly unstoppable on "Sunday Night Football," while Indy was blown out at home. Will either narrative change today?
Buffalo at Miami, 1 p.m. on FOX
The Dolphins almost made the playoffs last season until Buffalo embarrassed them in Week 17. This will serve as a revenge game, as Miami was the only AFC East team to win a game last week and can extend their division lead on the rival Bills.
San Francisco at Philadelphia, 1 p.m. on FOX
The 49ers and Eagles were two of the nine teams to score 30 or more points in the season opener, so this has high-scoring potential if the San Francisco offense is ready for a game at 10 a.m. body time.
Las Vegas at Pittsburgh, 1 p.m. on CBS
Both teams scored impressive upset wins over AFC North playoff teams last week, making this a far more interesting game than anticipated heading into the season. Las Vegas may have a challenge on offense without running back Josh Jacobs as the offensive line will try to slow down All-Pro pass rusher T.J. Watt and Co.
Denver at Jacksonville, 1 p.m. on CBS
Trevor Lawrence is set to make his home debut, and Jaguar fans were hoping for a lot more than they got last week in a blowout loss to the Texans. That will be a tall order against a Denver team that remains dangerous even without wideout Jerry Jeudy.
Minnesota at Arizona, 4:05 p.m. on FOX
After an impressive Week 1 showing in Nashville, the Cardinals return home to host the 0-1 Vikings. This could tell us a lot about each team's playoff chances after they finished one game apart last season.
Atlanta at Tampa Bay, 4:05 on FOX
Arthur Smith's head coaching debut did not go swimmingly, and now he's a double-digit underdog in his second game. Tough way to start your tenure.
Dallas at Los Angeles Chargers, 4:25 pm. on CBS
The Cowboys and Chargers should have two of the league's best offenses this season, which will make this perhaps the most entertaining of the late-afternoon games this week.
Tennessee at Seattle, 4:25 p.m. on CBS
Russell Wilson is allowed to cook again now that offensive coordinator Shane Waldron is calling plays in Seattle. Can he keep that going against a Titans team looking to bounce back after a week 1 loss?
This could be the best quarterback matchup of the season. Patrick Mahomes and Lamar Jackson in prime time? That’s hard to beat.