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NFL Picks Against the Spread (ATS) for Week 1

Road favorites dominate the season-opening slate as the NFL gets back to its on-field business.

The NFL is back and it comes out swinging with several must-see Week 1 matchups lined up to kick the 2022 season off. Besides the marquee quarterback pairings and other aspects of this week's slate, let's not forget about the Vegas factor.

Related: Expert Picks for Every NFL Game in Week 1

And for Week 1 that means a lot of small point spreads. As of Thursday morning, no team was favored by more than a touchdown. Perhaps that's because there are so many road favorites on the board, including in all three of the prime-time games. 

Here's how Athlon's own Steven Lassan (@AthlonSteven), Mark Ross (@AthlonMarkR), and Ben Weinrib (@benweinrib), along with AthlonSports.com contributor Bryan Fischer (@BryanDFischer) see Week 1 playing out when it comes to picking against the spread.

NFL Week 1 Picks Against the Spread

SpreadBryan FischerSteven LassanMark RossBen Weinrib

Buffalo at Los Angeles Rams (TNF)

BUF -2.5

Bills

Bills

Bills

Rams

New Orleans at Atlanta

NO -5.5

Saints

Saints

Falcons

Falcons

Cleveland at Carolina

EVEN

Panthers

Panthers

Panthers

Panthers

San Francisco at Chicago

SF -7

49ers

49ers

49ers

49ers

Pittsburgh at Cincinnati

CIN -6.5

Steelers

Steelers

Bengals

Steelers

Philadelphia at Detroit

PHI -5

Eagles

Lions

Eagles

Eagles

Indianapolis at Houston

IND -7

Colts

Texans

Colts

Colts

New England at Miami

MIA -3.5

Dolphins

Patriots

Dolphins

Patriots

Baltimore at New York Jets

BAL -6.5

Ravens

Ravens

Ravens

Ravens

Jacksonville at Washington

WAS -32.5

Jaguars

Jaguars

Jaguars

Commanders

Kansas City at Arizona

KC -64.5

Chiefs

Cardinals

Cardinals

Cardinals

Las Vegas at Los Angeles Chargers

LAC -3.5

Chargers

Raiders

Chargers

Chargers

Green Bay at Minnesota

GB -1.5

Packers

Packers

Packers

Packers

New York Giants at Tennessee

TEN -5.5

Giants

Titans

Titans

Titans

Tampa Bay at Dallas (SNF)

TB -2.5

Buccaneers

Buccaneers

Buccaneers

Cowboys

Denver at Seattle (MNF)

DEN -6.5

Broncos

Broncos

Broncos

Seahawks