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NFL Picks Against the Spread (ATS) for Week 2

NFL Picks Against the Spread (ATS) for Week 2

NFL Picks Against the Spread (ATS) for Week 2

The second week of the NFL season has some fun matchups on tap, including quarterback battles between Russell Wilson and Cam Newton (Seahawks vs. Patriots for "Sunday Night Football"), Baker Mayfield vs. Joe Burrow (Browns vs. Bengals, Thursday night), and Carson Wentz vs. Jared Goff (Eagles vs. Rams), just to name a few. But the real battle is on the boards with the point spread.

Week 2 offers some tough lines to consider as we are still trying to adjust to a new NFL season without the benefit of a preseason. It may still be another week before we truly have a firm grip on things, but it's time once again to pick out some lines that are screaming to be seen. And there are some enticing ones on the board this weekend around the National Football League.

Note: All times are ET and all games are on Sunday, Sept. 20.

Here are this week’s best NFL picks against the spread:

Green Bay (-6) vs. Detroit, 1 p.m.

It can be dangerous betting against the Packers, but the Lions managed to keep things tight last season. In each of their two meetings, the Packers won by a combined total of four points. But the Packers are coming off a 43-point explosion against the Vikings in their season opener and may have too much firepower to see the Lions keep up. Green Bay 27, Detroit 20

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San Francisco (-7) at New York Jets, 1 p.m.

The reigning NFC champs are coming off a tough loss against the Cardinals, but a game against the Jets figures to be a good rebound opportunity. Last season, San Francisco won every game after its three regular-season losses. Those wins were close, but they were also against stiffer competition than the Jets. The 49ers win comfortably, which should make the cross-country trip home more enjoyable. San Francisco 31, Jets 17

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Carolina (+9.5) at Tampa Bay, 1 p.m.

The Panthers let us down last week by failing to cover the spread by one point against the Raiders. But they’ll make it up to us this week with a larger spread to counter against Tom Brady and the new-look Bucs. Tampa Bay 26, Carolina 23

NFL Power Rankings: Panthers

Kansas City (-8.5) at Los Angeles Chargers, 4:25 p.m.

The Chargers may have a solid defense, but the Chiefs have Patrick Mahomes. After a 14-point victory in the NFL season opener last Thursday, the Chiefs look to score big on the road in their first division contest of the season. The Chiefs manage a late score to pad the lead enough to get the cover. Chiefs 34, Chargers 24

NFL Power Rankings: Chiefs

Baltimore (-7) at Houston, 4:25 p.m.

The NFL schedule-makers are not showing any mercy to Deshaun Watson and the Houston Texans. A week after facing reigning Super Bowl champion Kansas City, the Texans head home to take on Lamar Jackson and the Ravens. Baltimore is coming off a blowout and looks to be as complete a team as there may be. While the quarterback battle of Watson and Jackson should be entertaining, the Ravens make the defensive plays to keep the Texans out of the end zone just enough to score another solid win to start the season. Ravens 28, Texans 20

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— Written by Kevin McGuire, who is part of the Athlon Contributor Network. Follow him on Patreon, on Twitter @KevinOnCFB, on Instagram, and Like him on Facebook.