Carson Wentz and the winless Eagles are heavy road underdogs against the beat-up 49ers
This week the NFL faces its first challenge of the COVID era with Tennessee and Pittsburgh being wiped from the Week 4 slate. But life in the NFL will continue as the NFC East looks to fight for any amount of respectability it can still muster. This may not be the best week for that to happen with a few tough draws on the slate for Week 4.
Buckle up. We're including the entire NFC East in this week's batch of picks against the spread, for better or worse.
Note: All times are ET and all games are on Sunday, Oct. 4.
Here are this week's best NFL picks against the spread:
Indianapolis (-2.5) at Chicago, 1 p.m.
Nick Foles has taken over at quarterback for the Bears after his big comeback against Atlanta, but his team has been flirting with the loss column, and is about to take its first of the season. The Colts' defense will lead the way and ask Philip Rivers to score just enough points to get out of Chicago with a win. Colts 24, Bears 17
Dallas (-4.5) vs. Cleveland, 1 p.m.
The Cowboys have been one of the most entertaining 1-2 teams in the NFL with games going down to the wire each week. Could that trend continue this week? It might be possible with Baker Mayfield and the Browns putting up 69 points in their last two games. Dallas is due for a more relaxing end to the game, and will get it this weekend. Cowboys 31, Browns 23
Baltimore (-13) at Washington, 1 p.m.
After getting run over by Kansas City on Monday night, Lamar Jackson and the Ravens should have a get-right type of game this weekend against Washington. Expect a big game from Jackson as the Ravens dominate their way to a runaway victory. Ravens 38, Washington 17
Los Angeles Rams (-12) vs. New York Giants, 4:05 p.m.
The NFC East is a messy division, and the Giants are coming off a 36-9 setback against the 49ers. It won't be any easier on the road against Aaron Donald and the Rams. Donald will make it a long afternoon for Giants quarterback Daniel jones as the G-Men have a major problem on the offensive line. Rams 33, Giants 13
Philadelphia (+7) at San Francisco, 8:20 p.m. (SNF)
Bad things have certainly been happening in Philadelphia. The Eagles are a woeful 0-2-1 after playing for a tie against the Bengals on Sunday. With their backs against the wall and the temperature hitting a boiling point with the fans, the Eagles must find a way to show up on the road against the defending NFC champions, who are beat up and dealing with their own problems. The Eagles manage to not only cover, but pick up their first win of the year in shocking fashion. Eagles 24, 49ers 23
Last week: 3-2
Season to date: 9-6