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NFL Picks Against the Spread (ATS) for Week 6

Carson Wentz, Indianapolis Colts

After Monday's night heartbreaking overtime loss in Baltimore, Carson Wentz and Indianapolis look to get back on track as heavy home favorites against lowly Houston

Week 6 of the 2021 NFL season ushers in the start of the bye weeks, but all that means from a Vegas standpoint is fewer games to get aggravated about. Perhaps a lighter slate is a good thing considering that a pair of overtime games last week, combined with a couple of heavy favorites not coming through, no doubt caused plenty of bettors some headaches.

Related: Expert Picks for Every NFL Game in Week 6

As for the slightly smaller Week 6 lineup, there's another game over in London while the other matchups are trending towards more road favorites than home teams, including a handful of sizeable spreads for the visitors.

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Here's how Athlon's own Rob Doster (@AthlonDoster), Steven Lassan (@AthlonSteven), and Ben Weinrib (@benweinrib), see Week 6 playing out when it comes to picking against the spread.

NFL Week 6 Picks Against the Spread

Teams on bye: Atlanta, New Orleans, New York Jets, San Francisco

SpreadRob DosterSteven LassanBen Weinrib

Tampa Bay at Philadelphia (TNF)

TB -7

Buccaneers

Buccaneers

Buccaneers

Miami vs. Jacksonville (London)

MIA -3.5

Dolphins

Dolphins

Dolphins

Los Angeles Chargers at Baltimore

BAL -3

Chargers

Chargers

Chargers

Minnesota at Carolina

MIN -1

Panthers

Vikings

Panthers

Green Bay at Chicago

GB -4.5

Packers

Packers

Packers

Cincinnati at Detroit

CIN -3.5

Bengals

Lions

Lions

Houston at Indianapolis

IND -10

Colts

Colts

Texans

Los Angeles Rams at New York Giants

LAR -9.5

Rams

Rams

Giants

Kansas City at Washington

KC -6.5

Chiefs

Chiefs

Chiefs

Arizona at Cleveland

CLE -3

Cardinals

Cardinals

Browns

Las Vegas at Denver

DEN -3.5

Broncos

Raiders

Raiders

Dallas at New England

DAL -3.5

Cowboys

Cowboys

Cowboys

Seattle at Pittsburgh (SNF)

PIT -5

Seahawks

Steelers

Seahawks

Buffalo at Tennessee (MNF)

BUF -5.5

Titans

Titans

Bills

Week 5

11-5

10-6

8-8

Season Total*

36-28

35-29

29-35

*Season total does not include Week 1. Spreads are subject to change.