Peyton Manning's Broncos hit the road to take on Cam Newton's struggling Panthers.
A betting preview of every game (against the spread) on Sunday and Monday in Week 10.
Locks of the Week
Take the Manning Bros. to cover on the road against a pair of teams with a combined 1â7 record over their last four games.
Giants (-4) at Bengals
The Bungles are on a four-game slide and 1â3 at home, with their only win in Cincy coming against Cleveland in Week 2.
Broncos (-4.5) at Panthers
Other than a 36â7 loss to the Giants in Week 3, the Cats have lost by an average margin of 3.6 points in their other five defeats.
Itâs a particularly good week for powerhouse home teams to mop up some of the worst teams in the league.
Ravens (-9) vs. Raiders
From 2007-11, Eastern Time Zone home teams have a 44â15 record against Pacific Time Zone road teams.
Patriots (-11) vs. Bills
New England is 17â1 against Buffalo in its last 18 games, including a 52â28 blowout victory in Week 4.
49ers (-11.5) vs. Rams
The Niners are 9â2 at home under coach Jim Harbaugh, including a 26â0 win over St. Louis at Candlestick Park in Week 13 last year.
Steelers (-12.5) vs. Chiefs
K.C. has a -107 point differential, losing by 13.4 points per game. The No. 1 defense should take advantage of a team with a league-worst 29 turnovers.
Straight Up Upsets
Take the home teams in these division-rivalry showdowns, which are nearly pick âem games as it is.
Eagles (+2) vs. Cowboys
Phillyâs âDream Teamâ beat the Boys twice, 34â7 in Week 8 and 20â7 in Week 16, last season.
Vikings (+2) vs. Lions
The curse of Samantha Steele ends this week for Christian Ponder.
Saints (+3) vs. Falcons
Atlanta has a 2â6 record against New Orleans and a 1â3 mark in the Big un-Easy with Matt Ryan at QB.
Stay away from these contests completely, unless youâre a hometown homer or a degenerate who has to have action.
Bears (-1) vs. Texans
Matt Schaub is 10â1 over his last 11 games; Jay Cutler is 12â1 dating back to before his season-ending injury last year.
Buccaneers (-3) vs. Chargers
The âMuscle Hamsterâ of Doug Martin will take on the âTurkey Neckâ of Norv Turner.
Dolphins (-6) vs. Titans
Tennesseeâs Jake Locker returns from a left non-throwing shoulder injury, while Bud Adams gets his firing squad ready.
Seahawks (-6) vs. Jets
The Hawks are 4â0 at CenturyLink Field this season, while the Jetlags have been sluggish wherever they play.